DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and GRID1

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	794	Identity:	152/794 - (19%)
Similarity:	245/794 - (30%)	Gaps:	261/794 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 AQSNSEWL----------------EGVLRMEALRQI---------------AVVDLACGAVSRRF 169
            |..:|.|:                ..:.||..:|||               .:..|.|.. ...:
Human   249 ASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDP-QEGY 312

  Fly   170 LELASAKMLY--------SEKFHWLLIEDFAWHG-------RTQTAEGSGKRD------------ 207
            |::.....||        :..||..| ||..||.       |..|...:|.|.
Human   313 LQMLQISNLYLYDSVLMLANAFHRKL-EDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG 376

  Fly   208 -DGEMEEEEPPGQQIQATDDEDLPSIE-SFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPGLN 270
             .|.||..|          |...|.:: ..||  ..|..   |..|.|.:.|      .|:....
Human   377 LTGVMEFRE----------DSSNPYVQFEILG--TTYSE---TFGKDMRKLA------TWDSEKG 420

  Fly   271 YGGHVNLTEIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLTHTM 335
            ..|.:....:||  ..:|:.|    :..:.:....           |:..:|:.|....|
Human   421 LNGSLQERPMGS--RLQGLTL----KVVTVLEEPF-----------VMVAENILGQPKRY----- 463

  Fly   336 SGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGY---VKNGRFDGMIGALIRNETDIGGAPIF 397
                   ..|:.::|.|:.....:.:.:.:.....|   :.|..::||||.||....|:..:.|.
Human   464 -------KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAIT 521

  Fly   398 YWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFL-QPFTNDVWILIVGCGVLTVFILWFLT 461
            ...||...:|.:.|........:.:.|.  :|..|..| .||...||..|.....:...:::.|.
Human   522 ITPERESVVDFSKRYMDYSVGILIKKPE--EKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLN 584

  Fly   462 TIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDS 526
            .|:          .::.:..|.||
Human   585 RIQ----------AVRAQSAAQPR----------------------------------------- 598

  Fly   527 TPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFV-GIICQQGLGFSTSFVSGRC 590
             |..:.|                              |.|.::.| |...|||...|.:.::.|.
Human   599 -PSASAT------------------------------LHSAIWIVYGAFVQQGGESSVNSMAMRI 632

  Fly   591 IVITSLLFSFCIYQFYSASIVGTLL---MEKPKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKD 652
            ::.:..||:..:...|:|::...|.   |:.|  |:|..||   |.:|.|.        :...:|
Human   633 VMGSWWLFTLIVCSSYTANLAAFLTVSRMDNP--IRTFQDL---SKQVEMS--------YGTVRD 684

  Fly   653 PVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDP--AKSYRDIVHSHETGAHAKDNAASNWL 715
            ....|.:..|.|                  ||:..|.  |:.:|.|  |...||   ||..|:
Human   685 SAVYEYFRAKGT------------------NPLEQDSTFAELWRTI--SKNGGA---DNCVSS-- 724

  Fly   716 DPETGL--LRHLGFAFHVDVAAA-YKIIAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKV 776
             |..|:  .:...:||..|||.. |..:.:     |.|.:|.:......|...| :|..||.|.:
Human   725 -PSEGIRKAKKGNYAFLWDVAVVEYAALTD-----DDCSVTVIGNSISSKGYGIALQHGSPYRDL 783

  Fly   777 ISYGLRRVTETGILTYHFNVWHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTE 841
            .|..:..:.:||.|......|......|       ||.......:....:.|.|:|....||...
Human   784 FSQRILELQDTGDLDVLKQKWWPHMGRC-------DLTSHASAQADGKSLKLHSFAGVFCILAIG 841

  Fly   842 ILYSKWHNRIQLKW 855
            :|.:.....::|.|
Human   842 LLLACLVAALELWW 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	26/117 (22%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	64/274 (23%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		41/211 (19%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	38/196 (19%)
		ANF_receptor	41..400	CDD:279440	32/164 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	100/524 (19%)
		Lig_chan	564..841	CDD:278489	79/409 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740