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Protein Alignment Ir64a and GRIA3

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	796	Identity:	150/796 - (18%)
Similarity:	250/796 - (31%)	Gaps:	259/796 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 DVLAQSPTSGRPNRPGNGPTGGF----SQTPSQAQSNSEWLEGVLRMEALRQIAVVDLACGAVSR 167
            |:|.:....|..|      ..||    ::.|...|....|    :|::               .|
Human   254 DILLERVMHGGAN------ITGFQIVNNENPMVQQFIQRW----VRLD---------------ER 293

  Fly   168 RFLELASAKMLY------------SEKFHWLLIEDFAWHGRTQTAEGS--GKRDDGEMEEEEPPG 218
            .|.|..:|.:.|            :|.|.:|         |.|..:.|  |...|.......|..
Human   294 EFPEAKNAPLKYTSALTHDAILVIAEAFRYL---------RRQRVDVSRRGSAGDCLANPAVPWS 349

  Fly   219 QQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWN---PGLNYGGHVNLTEI 280
            |.|.......:..::...|  |:..:|       .....:||: ||:.   .|....|:.|  |.
Human   350 QGIDIERALKMVQVQGMTG--NIQFDT-------YGRRTNYTI-DVYEMKVSGSRKAGYWN--EY 402

  Fly   281 GSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVT------------NKNMTGTLMYY--- 330
            ..|.|....|:..            |...:..|.:||.|            ::.:.|...|.
Human   403 ERFVPFSDQQISN------------DSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYC 455

  Fly   331 --LTHTMSGHIDTMNRFNFNLLM------AVRDMFNWTFVLSRTTSWGYVKNGRFDGMIGALIRN 387
              |.:.::.|:    |..:.|.:      ..||        ..|..|        :||:|.|:..
Human   456 VDLAYEIAKHV----RIKYKLSIVGDGKYGARD--------PETKIW--------NGMVGELVYG 500

  Fly   388 ETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIV----G 448
            ..||..||:...|.|.:.||.:....|.....:.:.|:.::.....||.|...::|:.||    |
Human   501 RADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIG 565

  Fly   449 CGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSK 513
            ..|: :|::...:..||.|
Human   566 VSVV-LFLVSRFSPYEWHL---------------------------------------------- 583

  Fly   514 EKVEEKQEEYED-STPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQ 577
               |:..||..| .:|.|                         .|...|:| .|:.|.:|...||
Human   584 ---EDNNEEPRDPQSPPD-------------------------PPNEFGIF-NSLWFSLGAFMQQ 619

  Fly   578 GLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEK-PKTIKTLSDLV-HSSLKVGMEDI 640
            |...|...:|||.:......|:..|...|:|::...|.:|: ...|::..||. .:.:..|..|.
Human   620 GCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDS 684

  Fly   641 LYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAH 705
            ...:::|..:|..|..:::                                ||   :.|.|....
Human   685 GSTKEFFRRSKIAVYEKMW--------------------------------SY---MKSAEPSVF 714

  Fly   706 AKDNAASNWLDPETGLLRHLG-FAFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSI-MQ 768
            .|..|     |....:.:..| |||.::     ..:.|...::..||..:|......|...: ..
Human   715 TKTTA-----DGVARVRKSKGKFAFLLE-----STMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 769

  Fly   769 KNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPC-----VKKIETSDLHVDMDTVSSALLILL 828
            |.|.:|..::..:.::.|.|:|....|.|...|..|     ..|.:||.|  .:..|:....||:
Human   770 KGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSAL--SLSNVAGVFYILV 832

  Fly   829 FSYAITLMILGTEILY 844
            ....:.:|:...|..|
Human   833 GGLGLAMMVALIEFCY 848

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.