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Protein Alignment Ir64a and GRIA2

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	688	Identity:	124/688 - (18%)
Similarity:	227/688 - (32%)	Gaps:	204/688 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 RTQTAEGSGKRDDGE--MEEEEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAH 258
            |.|..|.|.:.:.|:  .....|.||.::.........:|...|.:....|     .||:    :
Human   315 RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQN-----GKRI----N 370

  Fly   259 YT--LFDVWNPGLNYGGH--------VNLTEIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVR 313
            ||  :.::...|....|:        |.|||:.|...|.|::..|
Human   371 YTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKT-------------------- 415

  Fly   314 CMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVKNGRF- 377
              ||||....:..:|....|.|....:....:..:|...:.....:.:.|:      .|.:|::
Human   416 --VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT------IVGDGKYG 472

  Fly   378 ---------DGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIV 433
                     :||:|.|:..:.||..||:...|.|.:.||.:....|.....:.:.|:.::.....
Human   473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS 537

  Fly   434 FLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQ 494
            ||.|...::|:.||    |..|: :|::...:..||
Human   538 FLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEW----------------------------- 572

  Fly   495 EQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPER 559
                                    ..||:||.                      |:.:..::...
Human   573 ------------------------HTEEFEDG----------------------RETQSSESTNE 591

  Fly   560 VGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEK-PKTIK 623
            .|:| .|:.|.:|...|||...|...:|||.:......|:..|...|:|::...|.:|: ...|:
Human   592 FGIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE 655

  Fly   624 TLSDL-VHSSLKVGMEDILYNRDYFLHTKDPVSMELY-----AKKITSVPTTKENEADEDEPVDP 682
            :..|| ..:.:..|..|....:::|..:|..|..:::     |:....|.||.|..|
Human   656 SAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVA-------- 712

  Fly   683 NPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFSEQ 747
                        .:..|....|:..::..:.:::                             ::
Human   713 ------------RVRKSKGKYAYLLESTMNEYIE-----------------------------QR 736

  Fly   748 DICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPC-----VK 806
            ..||..:|......|...| ..|.|.:|..::..:.:::|.|:|....|.|...|..|     ..
Human   737 KPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGS 801

  Fly   807 KIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844
            |.:||.|  .:..|:....||:....:.:::...|..|
Human   802 KEKTSAL--SLSNVAGVFYILVGGLGLAMLVALIEFCY 837

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.