DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and GRIA1

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001244950.1	Gene:	GRIA1 / 2890	HGNCID:	4571	Length:	916	Species:	Homo sapiens

Alignment Length:	645	Identity:	117/645 - (18%)
Similarity:	214/645 - (33%)	Gaps:	206/645 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 NPGLNYGGHVNLTEIGSFTPTEG----IQLHTWFRTTSTVRRRMDMQHARVR----------CMV 316
            ||.:.:|..:::.........||    :|.:...|.|:.....::|:|..:|          .:.
Human   336 NPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVP 400

  Fly   317 VVTN----------KNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFV-----LSRT 366
            ..|:          :|.|     |:..|:......|.:.|.|.... .|.:....|     :::.
Human   401 AATDAQAGGDNSSVQNRT-----YIVTTILEDPYVMLKKNANQFEG-NDRYEGYCVELAAEIAKH 459

  Fly   367 TSWGY----VKNGRF----------DGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRP 417
            ..:.|    |.:|::          :||:|.|:....|:..||:...|.|.:.||.:....|...
Human   460 VGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGI 524

  Fly   418 CFIFRHPRSTQKDRIVFLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHDGSALIKP 478
            ..:.:.|:.::.....||.|...::|:.||    |..|: :|::...:..||.
Human   525 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEWH------------ 576

  Fly   479 KGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLN 543
                                                  .|:.||..|.|..|          :.|
Human   577 --------------------------------------SEEFEEGRDQTTSD----------QSN 593

  Fly   544 KYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSA 608
            ::               |:| .|:.|.:|...|||...|...:|||.:......|:..|...|:|
Human   594 EF---------------GIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 642

  Fly   609 SIVGTLLMEK-PKTIKTLSDL------VHSSLKVGMEDILYNRDYFLHTKDPV--SMELYAKKIT 664
            ::...|.:|: ...|::..||      .:.:|:.|.     .:::|..:|..|  .|..|.|
Human   643 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGS-----TKEFFRRSKIAVFEKMWTYMK--- 699

  Fly   665 SVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLR---HLG 726
                                 |.:|:...|                     ..|.|::|   ..|
Human   700 ---------------------SAEPSVFVR---------------------TTEEGMIRVRKSKG 722

  Fly   727 -FAFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGI 789
             :|:.::     ..:.|...::..||..:|......|...| ..|.|.:|..::..:.::.|.|:
Human   723 KYAYLLE-----STMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGL 782

  Fly   790 LTYHFNVWHSRKPPC-----VKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844
            |....|.|...|..|     ..|.:||.|  .:..|:....||:....:.:::...|..|
Human   783 LDKLKNKWWYDKGECGSGGGDSKDKTSAL--SLSNVAGVFYILIGGLGLAMLVALIEFCY 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	27/136 (20%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	58/283 (20%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	11/62 (18%)
		ANF_receptor	47..382	CDD:279440	8/45 (18%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	95/518 (18%)
		Lig_chan	548..827	CDD:278489	75/412 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840