Protein Alignment Ir64a and Grin2b

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_036706.1
• Gene: Grin2b / 24410
• RGDID: 2738
• Length: 1482
• Species: Rattus norvegicus
• Alignment Length: 236
• Identity: 48/236 - (20%)
• Similarity: 79/236 - (33%)
• Gaps: 64/236 - (27%)

  Fly   280 IGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNR 344
            :.|..|..|    |..|.|             |.|...:.::|.|.....|:.....|
  Rat   419 VESVDPLSG----TCMRNT-------------VPCQKRIISENKTDEEPGYIKKCCKG------- 459

  Fly   345 FNFNLLMAVRDMFNWTFVLSRTTSWGYVK--NGRFDGMIGALIRNETDIGGAPIFYWLERHKWID 407
            |..::|..:.....:|:.|...|:..:.|  ||.::||||.::.....:....:....||.:.:|
  Rat   460 FCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVD 524

  Fly   408 VAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWI------LIVGCGVLTVF----------- 455
            .:.....:....:......|.... .||:||:.|||:      |||....:.||
  Rat   525 FSVPFIETGISVMVSRSNGTVSPS-AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRC 588

  Fly   456 ----------------ILWFLTTIEWKLVPHDGSALIKPKG 480
                            .:|.|    |.||.::...:..|||
  Rat   589 LADGREPGGPSFTIGKAIWLL----WGLVFNNSVPVQNPKG 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	28/148 (19%)
		Lig_chan	563..828	CDD:459656
Grin2b	NP_036706.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	48/236 (20%)
		Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489	604..623		5/22 (23%)
		NMDAR2_C	840..1482	CDD:463148
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1269..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding	1480..1482