DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir64a and Grin3a

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	824	Identity:	147/824 - (17%)
Similarity:	264/824 - (32%)	Gaps:	247/824 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 QSNSEW-LEGVLRMEA---------------LRQI-----AVVDLAC--GAVSRRFLELASAKML 178
            ::||:: ||.::.:.|               |..|     .:|...|  |:: |:..|:::...|
Mouse   284 ENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSI-RQIFEMSTQFGL 347

  Fly   179 YSEKFHWLL-----IEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGG 238
            .....||:|     :|:....|........||......|.......::.|........|:..|..
Mouse   348 SPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELAL 412

  Fly   239 MNLYMN------TELTLAKRMSEAAHYTLFD---------------------VWNPGLNYGGHVN 276
            :...||      |.||..:.:|.....|.|.                     :||...:..|...
Mouse   413 LPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPM 477

  Fly   277 LTEIGSFT-----------PTEGIQLHTWFRTTSTVRRRMD--MQH---------------ARVR 313
            .|.:||:.           |.:..:..|.|...:.:..|:.  ::|               |...
Mouse   478 WTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQL 542

  Fly   314 CMVVVTNKNMTGTLMYYLTHTMSGHIDTMNR-----FNFNLLMAVRDMFNWTFVL-----SRTTS 368
            |:..:||.:.....::...|:.:..:....:     :..:||..:.:..|:.|.|     .:..:
Mouse   543 CLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGA 607

  Fly   369 WGYVKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIV 433
            |   |||.:.|::|.|:....::..........|.:.||.....:|:....:.| .|.|......
Mouse   608 W---KNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVR-TRDTAAPIGA 668

  Fly   434 FLQPFTNDVWI-LIVGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQV 497
            |:.|....:|: :.|...:..:    |||..|||          .|.|..|
Mouse   669 FMWPLHWTMWLGIFVALHITAI----FLTLYEWK----------SPFGMTP-------------- 705

  Fly   498 EAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGL 562
                             |...:.:.:..|:.::.      ||..|    ..|.|..|......|.
Mouse   706 -----------------KGRNRNKVFSFSSALNV------CYALL----FGRTAAIKPPKCWTGR 743

  Fly   563 FLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSD 627
            ||.::.   .|.|.                       ||: ..|:|::...::.||
Mouse   744 FLMNLW---AIFCM-----------------------FCL-STYTANLAAVMVGEK--------- 772

  Fly   628 LVHSSLKVGMEDILY---NRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPV---S 686
             ::..|. |:.|...   ::.:...|....|.|.|.::  |.|...|.....:.|..|:.|   .
Mouse   773 -IYEELS-GIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEMHEYMRRYNVPATPDGVQYLK 833

  Fly   687 TDPAKSYRDIVHSHETGAHAKDNAASNW---LDPETGLLRHLGFAFHVDVAAAYKIIAETFSEQD 748
            .||.|          ..|...|.|..::   :|.:..||. :|..|.::   .|.|
Mouse   834 NDPEK----------LDAFIMDKALLDYEVSIDADCKLLT-VGKPFAIE---GYGI--------- 875

  Fly   749 ICDLTEVSMFPPQKTVSIMQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPCVKK--IETS 811
                    ..||         |||:...||..:.:....|.:....:.|: :..||.|:  ..|.
Mouse   876 --------GLPP---------NSPLTSNISELISQYKSHGFMDVLHDKWY-KVVPCGKRSFAVTE 922

  Fly   812 DLHVDMDTVSSALLILLFSYAITLM-ILGTEILYSKWHNRIQLK 854
            .|.:.:...|...::|...:.:::: .:|..|:|.....||:.|
Mouse   923 TLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNK 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	24/119 (20%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	51/275 (19%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	38/213 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	92/534 (17%)
		Lig_chan	676..942	CDD:278489	72/401 (18%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		6/16 (38%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830