Protein Alignment Ir64a and Grin3a

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 824
• Identity: 147/824 - (17%)
• Similarity: 264/824 - (32%)
• Gaps: 247/824 - (29%)

  Fly   137 QSNSEW-LEGVLRMEA---------------LRQI-----AVVDLAC--GAVSRRFLELASAKML 178
            ::||:: ||.::.:.|               |..|     .:|...|  |:: |:..|:::...|
Mouse   284 ENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSI-RQIFEMSTQFGL 347

  Fly   179 YSEKFHWLL-----IEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGG 238
            .....||:|     :|:....|........||......|.......::.|........|:..|..
Mouse   348 SPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELAL 412

  Fly   239 MNLYMN------TELTLAKRMSEAAHYTLFD---------------------VWNPGLNYGGHVN 276
            :...||      |.||..:.:|.....|.|.                     :||...:..|...
Mouse   413 LPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPM 477

  Fly   277 LTEIGSFT-----------PTEGIQLHTWFRTTSTVRRRMD--MQH---------------ARVR 313
            .|.:||:.           |.:..:..|.|...:.:..|:.  ::|               |...
Mouse   478 WTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQL 542

  Fly   314 CMVVVTNKNMTGTLMYYLTHTMSGHIDTMNR-----FNFNLLMAVRDMFNWTFVL-----SRTTS 368
            |:..:||.:.....::...|:.:..:....:     :..:||..:.:..|:.|.|     .:..:
Mouse   543 CLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGA 607

  Fly   369 WGYVKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIV 433
            |   |||.:.|::|.|:....::..........|.:.||.....:|:....:.| .|.|......
Mouse   608 W---KNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVR-TRDTAAPIGA 668

  Fly   434 FLQPFTNDVWI-LIVGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQV 497
            |:.|....:|: :.|...:..:    |||..|||          .|.|..|
Mouse   669 FMWPLHWTMWLGIFVALHITAI----FLTLYEWK----------SPFGMTP-------------- 705

  Fly   498 EAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGL 562
                             |...:.:.:..|:.::.      ||..|    ..|.|..|......|.
Mouse   706 -----------------KGRNRNKVFSFSSALNV------CYALL----FGRTAAIKPPKCWTGR 743

  Fly   563 FLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSD 627
            ||.::.   .|.|.                       ||: ..|:|::...::.||
Mouse   744 FLMNLW---AIFCM-----------------------FCL-STYTANLAAVMVGEK--------- 772

  Fly   628 LVHSSLKVGMEDILY---NRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPV---S 686
             ::..|. |:.|...   ::.:...|....|.|.|.::  |.|...|.....:.|..|:.|   .
Mouse   773 -IYEELS-GIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEMHEYMRRYNVPATPDGVQYLK 833

  Fly   687 TDPAKSYRDIVHSHETGAHAKDNAASNW---LDPETGLLRHLGFAFHVDVAAAYKIIAETFSEQD 748
            .||.|          ..|...|.|..::   :|.:..||. :|..|.::   .|.|
Mouse   834 NDPEK----------LDAFIMDKALLDYEVSIDADCKLLT-VGKPFAIE---GYGI--------- 875

  Fly   749 ICDLTEVSMFPPQKTVSIMQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPCVKK--IETS 811
                    ..||         |||:...||..:.:....|.:....:.|: :..||.|:  ..|.
Mouse   876 --------GLPP---------NSPLTSNISELISQYKSHGFMDVLHDKWY-KVVPCGKRSFAVTE 922

  Fly   812 DLHVDMDTVSSALLILLFSYAITLM-ILGTEILYSKWHNRIQLK 854
            .|.:.:...|...::|...:.:::: .:|..|:|.....||:.|
Mouse   923 TLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNK 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	24/119 (20%)
		Lig_chan	563..828	CDD:459656	51/275 (19%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	38/212 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	92/534 (17%)
		Lig_chan	674..941	CDD:459656	72/402 (18%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		6/16 (38%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115