DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and glr-6

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	344	Identity:	69/344 - (20%)
Similarity:	109/344 - (31%)	Gaps:	110/344 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 LACGAVSRRFLELASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQAT 224
            |||.|..||.:.....:.:  :||...:::.|.......:..|:..|.|.|:.
Worm   311 LACQAGDRRIISCGDNEAV--KKFKLPIVKPFKGLTGKISFNGTSDRSDSELH------------ 361

  Fly   225 DDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLTEIGSFTPTEGI 289
                                                   :|..|        :|..|..|   ||
Worm   362 ---------------------------------------IWEMG--------ITGAGLHT---GI 376

  Fly   290 QLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLT-------------HTMSGHIDT 341
            ...||             :.::...|:.   ||:.||..:|..             |.....|:.
Worm   377 WKSTW-------------EGSKELTMLA---KNIPGTHEHYQASVRESRTLKVTSIHEKPYVIEK 425

  Fly   342 M--------NRFNFNLLMAVRDM--FNWTFVLSRTTSWGYVKNG--RFDGMIGALIRNETDIGGA 394
            :        ..|..:||..:.:|  ||:|..:.:...:|..|||  .:|||||.::|.:.|:..|
Worm   426 IMPDGRIKHEGFCVDLLDKLAEMLHFNYTLKIVKDNKYGERKNGTDEWDGMIGEILRGDADMAVA 490

  Fly   395 PIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIV-FLQPFTNDVWILIVGCGVLTVFILW 458
            ||.....|.:.||............:.|.|.......:. ||.|.:..||.......|:|.
Worm   491 PITVTATRLEVIDFTDPFLQLGISMLMRQPNPKSSSSLTRFLWPLSASVWTFSAIATVITA---- 551

  Fly   459 FLTTIEWKLVPHDGSALIK 477
            .|.|:...|.|.:.:|..|
Worm   552 LLVTVAAVLSPKESTAEFK 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	32/118 (27%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	24/162 (15%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	41/166 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010