DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and glr-5

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	898	Identity:	164/898 - (18%)
Similarity:	280/898 - (31%)	Gaps:	314/898 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PEH--ELLELELDYGLAEPQRTSLLQSSLILQFSQD---YKHIPRITYFTCQKPHLQTPNQIPNA 76
            |||  ..|...|..||.|.:...||.:..:.....:   |.|...|:.:......|
Worm   223 PEHTYTFLLASLQMGLIELKHWFLLTNMELSTMDMELFRYNHARFISPYPVDSTFL--------- 278

  Fly    77 AEHRDAFAAKNFQLIKSLYESELFVRIVLLDVLAQSPTSGRPNRPGNGPTGGFSQTPSQAQSNSE 141
            .|:||||   ||...|.          .:.:..|....:.|                     |.:
Worm   279 TENRDAF---NFSHFKE----------HITEKWAMKTDNSR---------------------NLK 309

  Fly   142 WLEGVLRMEALRQIAVVDLACGAVSRRFLELASAKML-------------YSEKFHWLLIEDFAW 193
            .:|.|...:|:...|.|          |.||:|...:             .|.|:.
Worm   310 MMEAVFTFDAVYAFANV----------FNELSSHMQMNDVPQTLCRKSSRNSRKYQ--------- 355

  Fly   194 HGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGGMN---LYMNTELTLAKRMSE 255
            |||:                      .|......||..:...|..:|   |..|..:.:     :
Worm   356 HGRS----------------------LIDNIVHNDLHGLSGDLRRLNGHPLKSNFSMRI-----Q 393

  Fly   256 AAHYT--LFDV--WNPGLNYGGHVNLTEIGSFTPTEGIQ----LHTWFRTTSTVRRRMDMQHARV 312
            ...|:  |.|:  |.|..|.  |||::..........:|    |...||.|:.:.|
Worm   394 LLGYSGRLDDIGFWEPATNV--HVNMSGDSKAQLQRNVQVSDELKPHFRVTTIMER--------- 447

  Fly   313 RCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFN---FNLLMAV-RDM-FNWTFVLSRTTSWGYV 372
              ..|:..||      :|       .:|..::|.   .:||..: :|: |.:|....:...:|..
Worm   448 --PYVMLKKN------HY-------ELDANSKFEGFCIDLLAELSKDLGFTYTIHAVKDGKYGND 497

  Fly   373 K--NGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFL 435
            |  ||.:|||:|.::|.|.::..||:.....|.:.:|......|.....:::.|...|.|...||
Worm   498 KYGNGSWDGMMGEILRGEAEMAVAPLTVNYRRSEAVDFTKPFLSLGISILYKVPDDQQPDLFSFL 562

  Fly   436 QPFTNDVWILIVGCGVLTVFI-LWF---LTTIEWKL--------VPHDGSALIKPKGGAPPRHHY 488
            .|.:..:|..| ...::||.: ::|   :|..||.|        .||..:|....:
Worm   563 NPLSWQIWTAI-ATSIITVTLGMYFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQ--------- 617

  Fly   489 QQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQ 553
                     |||        :|:|                              |.|
Worm   618 ---------EAP--------IVMS------------------------------NNY-------- 627

  Fly   554 KKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEK 618
                    .|..:|.:.:..:.:.|..|....||.|.:..|..:|...|...|:|::...|.:.:
Worm   628 --------SFWNTVWYVLSTMLKGGCDFGPRAVSTRLLGGTWWVFYLVIISAYTANLAAVLTVSR 684

  Fly   619 PK-TIKTLSDLV------HSSLKVGMEDILYNRDYFLHTK--DPVSMELYAKKITSVPTTKENEA 674
            |. .||.|.||.      :.:::.|.     ...:|..::  ..|.|..|.|
Worm   685 PYIPIKNLDDLANQTTISYGTIRGGS-----TMQFFQESRIAAHVKMWQYMK------------- 731

  Fly   675 DEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKI 739
            |:|..|..|....:.|.|                                :.:|:.::..:.
Worm   732 DKDVFVTSNGKGVERALS--------------------------------MNYAYLMESTSL--- 761

  Fly   740 IAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSP-----MRKVISYGLRRVTETGILTYHFNVWH 798
               .:..|..|:||::......|...| :.|.|.     .|:::.|..|.:.|.....:    |.
Worm   762 ---EYETQQNCNLTQIGGVLGSKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKTKW----WR 819

  Fly   799 SRKPPC---VKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWH 848
            |:...|   ...::.....:.|..|:...:.|.....:..:::..|:::...|
Worm   820 SKGAACASTASAVKHDRFALSMYNVAGLFITLGVGIVLAAIVVIFELIHRCHH 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	30/121 (25%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	49/282 (17%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	55/285 (19%)
		ANF_receptor	38..377	CDD:279440	42/237 (18%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	99/537 (18%)
		Lig_chan	568..855	CDD:278489	69/419 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910