Protein Alignment Ir64a and Grin3b

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 775
• Identity: 136/775 - (17%)
• Similarity: 238/775 - (30%)
• Gaps: 236/775 - (30%)

  Fly   136 AQSNSEWLEGV-LRMEALRQIAVVD--LACGAVSRRFLE-------------LASAKMLYSEKFH 184
            |....:||.|. |..|||....:..  ||.|...:..||             |:|..:::.|:.
  Rat   252 APPGPQWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPERA- 315

  Fly   185 WLL-----IEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGGMNLYMN 244
             ||     .:|.    :|..:|.:|:                         ::..|||..:....
  Rat   316 -LLPAVVNCDDL----KTGGSEATGR-------------------------TLARFLGNTSFQGR 350

  Fly   245 TELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLTEIGS-------FTP---------TEGIQLHT 293
            |........|:......|.||:...:..|......:||       |.|         ..|.|...
  Rat   351 TGAVWVTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARP 415

  Fly   294 WFRTTSTVR------RRMDMQ---HARVRCMVVVTNKN----------MTGTLMYYLTHTMSGH- 338
            ..|..:.|.      |..|..   .|...|:...||.:          :.|::...|.....|:
  Rat   416 KLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYC 480

  Fly   339 IDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVKNGRFDGMIGALIRNETDIGGAPIFYWLERH 403
            ||.:.|...:|      .|::...:.....:|.:::||:.|::|.|:.....:..........|.
  Rat   481 IDLLERLAEDL------AFDFELYIVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARS 539

  Fly   404 KWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFLTTIEWKLV 468
            :.:|.....:|:....:.| .|.|......|:.|....:|:.:.....||..   |||..||: .
  Rat   540 QVVDFTSPFFSTSLGIMVR-TRDTASPIGAFMWPLHWSMWVGVFAALHLTAL---FLTLYEWR-S 599

  Fly   469 PHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGT 533
            |:          |..||...:                                    .|.....:
  Rat   600 PY----------GLTPRGRNR------------------------------------GTVFSYSS 618

  Fly   534 LWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLF 598
            ....||..|  :.:...:|..|.|                             :||.::....:|
  Rat   619 ALNLCYAIL--FGRTVSSKTPKCP-----------------------------TGRFLMNLWAIF 652

  Fly   599 SFCIYQFYSASIVGTLLMEKPKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKI 663
            ...:...|:|::...::.:  ||.:.||.:....|....:...:.      |....|.|.|.|
  Rat   653 CLLVLSSYTANLAAVMVGD--KTFEELSGIHDPKLHHPSQGFRFG------TVWESSAEAYIK-- 707

  Fly   664 TSVPTTKENEADEDEPVDPNPV---STDPAKSYRDIVHSHETGAHAKDNAASNW---LDPETGLL 722
            .|.|....:......|..|:.|   ::||.|          ..|...|.:..::   :|.:..||
  Rat   708 ASFPEMHAHMRRHSAPTTPHGVAMLTSDPPK----------LNAFIMDKSLLDYEVSIDADCKLL 762

  Fly   723 RHLGFAFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSIMQKNSPMRKVISYGLRRVTET 787
            . :|..|.::   .|.|                          .:.:|||:...:|..:.|...:
  Rat   763 T-VGKPFAIE---GYGI--------------------------GLPQNSPLTSNLSEFISRYKSS 797

  Fly   788 GILTYHFNVWHSRKPPCVKKI--ETSDLHVDMDTVSSALLILLFSYAITLMI-LGTEILY 844
            |.:....:.|: :..||.|::  .|..|.:.:...|...::|.......|:. ||..:.|
  Rat   798 GFIDLLHDKWY-KMVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFY 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	21/113 (19%)
		Lig_chan	563..828	CDD:459656	45/272 (17%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	19..401	CDD:380600	35/179 (20%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	87/531 (16%)
		Lig_chan	574..841	CDD:459656	65/398 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250|UniProtKB:Q91ZU9	951..984