DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir64a and Grin2d

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	461	Identity:	92/461 - (19%)
Similarity:	146/461 - (31%)	Gaps:	159/461 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LAQSPTSGRPNR----PGNG--PTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVVDLACGAVSR 167
            ||....||.|..    ||..  |.|.|      |..::.|.:.:.|..| ..:|||.....|:.|
Mouse   281 LAGGGGSGVPGEPLLLPGGAPLPAGLF------AVRSAGWRDDLARRVA-AGVAVVARGAQALLR 338

  Fly   168 --RFL-EL-----ASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSG------------KRDD---- 208
              .|| ||     |..:....|..|...: :..|..|..:....|            .||.
Mouse   339 DYGFLPELGHDCRAQNRTHRGESLHRYFM-NITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEV 402

  Fly   209 -GEMEEE----EPP-----GQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFD 263
             |..|::    :.|     |:.:|..||                 ...||:|  ..|...:.:.:
Mouse   403 VGSWEQQTLRLKYPLWSRYGRFLQPVDD-----------------TQHLTVA--TLEERPFVIVE 448

  Fly   264 VWNPGLNYGGHVNLTEIGSFTPTEGIQLHTWFRTTSTVRRRM---DMQHARVRCMVVVTNKNMTG 325
            ..:|       ::.|.|....|... ||:   ||.|.|..|.   |......||.     |....
Mouse   449 PADP-------ISGTCIRDSVPCRS-QLN---RTHSLVAPRSPPPDAPRPEKRCC-----KGFCI 497

  Fly   326 TLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVKNGRFDGMIGALIRNETD 390
            .::..|.||:.                    |::...|......|...:|.::||||.:.....|
Mouse   498 DILKRLAHTIG--------------------FSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRAD 542

  Fly   391 IGGAPIFYWLERHKWID-------------VAGRSWSSRP----CFIFRHPRSTQKDRIVFLQPF 438
            :....:....||.:.:|             ||..:.:..|    .|.:..|..:.       :|:
Mouse   543 MAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLMPPMSP-------EPY 600

  Fly   439 TNDVWILI-VGC---GVLTVFILWFLTTIE-------------------------WKLVPHDGSA 474
            :..||::: |.|   ..:||||..:|:.:.                         |.||.::...
Mouse   601 SPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVP 665

  Fly   475 LIKPKG 480
            :..|:|
Mouse   666 VENPRG 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	27/159 (17%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	33/141 (23%)
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	54/285 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830