DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and Grin2a

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	728	Identity:	127/728 - (17%)
Similarity:	229/728 - (31%)	Gaps:	238/728 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LELASAKMLYSEKFHWLLIEDFAWHGRTQTAE--------------GSGKRDDGEMEEEEPPGQQ 220
            |..|::.||  |||.::.....:.:|:|:..|              ..||  |....||   |.|
Mouse   299 LTTAASSML--EKFSYIPEAKASCYGQTEKPETPLHTLHQFMVNVTWDGK--DLSFTEE---GYQ 356

  Fly   221 IQ-------ATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLT 278
            :.       ...|.:...:..:         ...||:.|.:....|..|....|..|:...|.|.
Mouse   357 VHPRLVVIVLNKDREWEKVGKW---------ENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412

  Fly   279 EIGSFTPTEGIQ--LHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGH-ID 340
            | ..|...|.|.  ..|..|.|...|:.:.:.::        ||:.|.      :.....|. ||
Mouse   413 E-APFVIVEDIDPLTETCVRNTVPCRKFVKINNS--------TNEGMN------VKKCCKGFCID 462

  Fly   341 TMNRFNFNLLMAVRDMFNWTFVLSRTTSWGY----VKNGR--------FDGMIGALIRNETDIGG 393
            .:.:                  ||||..:.|    |.||:        ::||||.::.....:..
Mouse   463 ILKK------------------LSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAV 509

  Fly   394 APIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILW 458
            ..:....||.:.:|.:.....:....:......|.... .||:||:..||::        :|::.
Mouse   510 GSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS-AFLEPFSASVWVM--------MFVML 565

  Fly   459 FLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEY 523
            .:                                           ::|::|.|           :
Mouse   566 LI-------------------------------------------VSAIAVFV-----------F 576

  Fly   524 EDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSF--- 585
            |..:|:.                .:|...:.|||......:...::.:     .||.|:.|.
Mouse   577 EYFSPVG----------------YNRNLAKGKAPHGPSFTIGKAIWLL-----WGLVFNNSVPVQ 620

  Fly   586 ----VSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSDLVHSSLKVGMEDILYNRDY 646
                .:.:.:|.....|:......|:|::...::.|:      ..|.|     .|:.|..:.|.
Mouse   621 NPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE------FVDQV-----TGLSDKKFQRP- 673

  Fly   647 FLHTKDPVSMELYAKKITSVPT-TKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNA 710
              |...|      ..:..:||. :.|.....:.|.....::....:...|.:.|.:||.
Mouse   674 --HDYSP------PFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQRGVEDALVSLKTGK------ 724

  Fly   711 ASNWLDPETGLLRHLGFAFHVDVAAA-YKIIAETFSEQDICDLTEVS---MFPPQKTVSIMQKNS 771
                ||           ||..|.|.. ||.     ...:.|.|..:.   :|........:||.|
Mouse   725 ----LD-----------AFIYDAAVLNYKA-----GRDEGCKLVTIGSGYIFATTGYGIALQKGS 769

  Fly   772 PMRKVISYGLRRVTETGILTYHFNVW-----HSRKPPCVKKIETSDLHVDMDTVSSALLILLFSY 831
            |.::.|...|.:....|.:.....:|     |:.|    .::.:|.|  |:|.::....:|..:.
Mouse   770 PWKRQIDLALLQFVGDGEMEELETLWLTGICHNEK----NEVMSSQL--DIDNMAGVFYMLAAAM 828

  Fly   832 AITLMILGTEILY 844
            |::|:....|.|:
Mouse   829 ALSLITFIWEHLF 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	23/125 (18%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	49/281 (17%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	21/108 (19%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	92/561 (16%)
		HisJ	<458..>541	CDD:223904	18/100 (18%)
		Lig_chan	556..828	CDD:278489	62/406 (15%)
		NMDAR2_C	839..1464	CDD:287527	1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930