Protein Alignment Ir64a and Grik3

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_001074566.1
• Gene: Grik3 / 14807
• MGIID: 95816
• Length: 919
• Species: Mus musculus
• Alignment Length: 582
• Identity: 102/582 - (17%)
• Similarity: 200/582 - (34%)
• Gaps: 152/582 - (26%)

  Fly   277 LTEIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLT-HTMSGHID 340
            |.::|.::|.:|:.:     |.....|..::..:.....::||.......:|:..: .|:.|: |
Mouse   402 LEKVGVWSPADGLNI-----TEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGN-D 460

  Fly   341 TMNRFNFNLLMAVRDMFNWTFVLSRTTSWGY---VKNGRFDGMIGALIRNETDIGGAPIFYWLER 402
            ....:..:||..:..:..:::.:.......|   ...|:::||:..||.::.|:..||:.....|
Mouse   461 RFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVR 525

  Fly   403 HKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVW--ILIVGCGVLTV-FILWFLTTIE 464
            .|.||.:....:.....::|.|..|......||.|.:.|:|  :|:...||..| |::...:..|
Mouse   526 EKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYE 590

  Fly   465 WKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPI 529
            |                                                          .|:.|.
Mouse   591 W----------------------------------------------------------YDAHPC 597

  Fly   530 DAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVIT 594
            :.|:                     :..|.....|.|..|.:|.:.|||.......:|.|.|...
Mouse   598 NPGS---------------------EVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGI 641

  Fly   595 SLLFSFCIYQFYSASIVGTLLMEKPKT-IKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSME 657
            ...|:..|...|:|::...|.:|:.:: |.:..||. .:.::.|.            .||..:|.
Mouse   642 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGA------------VKDGATMT 694

  Fly   658 LYAKKITSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLL 722
            .:.|  :.:.|.::..|.         :|:.|:             |..|:|        |.|:.
Mouse   695 FFKK--SKISTFEKMWAF---------MSSKPS-------------ALVKNN--------EEGIQ 727

  Fly   723 RHLGFAFHVDVAAAYKIIAET----FSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLR 782
            |.|        .|.|.::.|:    :..|..|:||::......|...| ....||.|..|:..:.
Mouse   728 RTL--------TADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAIL 784

  Fly   783 RVTETGILTYHFNVWHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844
            ::.|...|......|. |...|.::.......:.:..:....::|.....:::::...|.:|
Mouse   785 QLQEEDKLHIMKEKWW-RGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIY 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	26/119 (22%)
		Lig_chan	563..828	CDD:459656	53/271 (20%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate	37..417	CDD:380605	4/19 (21%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	91/500 (18%)