DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and Grik2

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	912	Identity:	164/912 - (17%)
Similarity:	300/912 - (32%)	Gaps:	282/912 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PHLQT--PNQIPNAAEHRDAFAAKNFQLIKSLYESEL----FVR-------------IVLLDVLA 110
            ||:||  .:|:   ::::|:|....:....||..:.|    |.:             ::.|..|.
Mouse   128 PHIQTRWKHQV---SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELI 189

  Fly   111 QSPTSGRPNRPGNGPTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVV-----DLACGAVSRRFL 170
            ::|:  |.|....     ..|.|:..:.....|:   .|:..::..|:     ::|.|     .|
Mouse   190 KAPS--RYNLRLK-----IRQLPADTKDAKPLLK---EMKRGKEFHVIFDCSHEMAAG-----IL 239

  Fly   171 ELASAKMLYSEKFHWLL---------IEDFAWHG---------RTQTAEGSGKRDDGEMEEEEPP 217
            :.|.|..:.:|.:|::.         :|.:.:.|         .|:..:.|...:...||..:.|
Mouse   240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304

  Fly   218 GQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDV------------------ 264
                        |..:|  |.::.:|.|:..|   |.:|.|.....|
Mouse   305 ------------PKPDS--GLLDGFMTTDAAL---MYDAVHVVSVAVQQFPQMTVSSLQCNRHKP 352

  Fly   265 WNPGLNY------------GGHV----------------------NLTEIGSFTPTEGIQLHTWF 295
            |..|..:            .|.:                      .|.:||::.|:.|:.:
Mouse   353 WRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPSSGLNM---- 413

  Fly   296 RTTSTVRRRMDMQHA-RVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNW 359
             |.|...:..::..: ..|.::|.|.......|.......:.|: |....:..:||..:..:..:
Mouse   414 -TESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGN-DRFEGYCIDLLRELSTILGF 476

  Fly   360 TFVLSRTTSWGYVK----NGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFI 420
            |:.:.......|..    ||:::||:..||.::.|:..||:.....|.|.||.:....:.....:
Mouse   477 TYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISIL 541

  Fly   421 FRHPRSTQKDRIVFLQPFTNDVW--ILIVGCGVLTV-FILWFLTTIEWKLVPHDGSALIKPKGGA 482
            :|.|..|......||.|.:.|:|  ||:...||..| |::...:...|...|:..
Mouse   542 YRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNCS---------- 596

  Fly   483 PPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQE-----EYE---------DSTPIDAGT 533
                ||...|:                .:..:.:|...|     .||         ||..::
Mouse   597 ----HYHHSQR----------------CLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVE--- 638

  Fly   534 LWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLF 598
                     |.:                ..|.|..|.||.:.|||.......:|.|.:......|
Mouse   639 ---------NNF----------------TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFF 678

  Fly   599 SFCIYQFYSASIVGTLLMEKPKT-IKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAK 661
            :..|...|:|::...|.:|:.:: |.:..||. .:.::.|.            .:|..:|..:.|
Mouse   679 TLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGA------------VEDGATMTFFKK 731

  Fly   662 KITSVPTTKENEADEDEPVDPNPVST-DPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHL 725
                                 :.:|| |...::   :.|.......|.|        |.|:.|.|
Mouse   732 ---------------------SKISTYDKMWAF---MSSRRQSVLVKSN--------EEGIQRVL 764

  Fly   726 GFAFHVDVAAAYKIIAET----FSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVT 785
                    .:.|..:.|:    |..|..|:||::......|...: ....||.|..|:..:.::.
Mouse   765 --------TSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQ 821

  Fly   786 ETGILTYHF---NVWHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKW 847
            |.|.|  |.   ..|.....|..:..|.|.|.|  ..:....::|.....:::.:...|.||...
Mouse   822 EEGKL--HMMKEKWWRGNGCPEEESKEASALGV--QNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 882

  Fly   848 HN 849
            .|
Mouse   883 KN 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	29/120 (24%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	55/275 (20%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	53/325 (16%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	98/517 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840