DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and Grid2

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	706	Identity:	124/706 - (17%)
Similarity:	237/706 - (33%)	Gaps:	212/706 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 MLYSEKFHWLLIEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGGMNL 241
            :|.:..||..| ||..||.....:         .:.:...|.|..::.    |.:|:.  ||:|
Mouse   332 LLLANAFHKKL-EDRKWHSMASLS---------CIRKNSKPWQGGRSM----LETIKK--GGVN- 379

  Fly   242 YMNTELTLAKRMSEA-AHYTLFDVWNPGLNYGGHV--NLTEIGSFTPTEGIQLHTWFRTTSTVRR 303
            .:..:|...:..... .|:.:.     |.|||..:  .:.::|.:.|..|:       ..|...:
Mouse   380 GLTGDLEFGENGGNPNVHFEIL-----GTNYGEELGRGVRKLGCWNPVTGL-------NGSLTDK 432

  Fly   304 RMDMQHARVRCMVVVTNKNMTGTLMYYLT----------HTMSGHIDTMNRFNFNLLMAVRDM-- 356
            :::              .||.|.::..:|          ..:.|.......|:.::|.|:.:.
Mouse   433 KLE--------------NNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLG 483

  Fly   357 FNWTFVLSRTTSWGY-VKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFI 420
            ||:...::....:|. .::|.::|::|.|:....|||.:.:....:|...:|...|........:
Mouse   484 FNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVL 548

  Fly   421 FRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPR 485
            .|....| .|....|.||...:|..|.|. ||.|.:|.:|  :.|.               .|||
Mouse   549 LRRAEKT-VDMFACLAPFDLSLWACIAGT-VLLVGLLVYL--LNWL---------------NPPR 594

  Fly   486 HHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRK 550
                         ..:..:|:.::.                     .::|
Mouse   595 -------------LQMGSMTSTTLY---------------------NSMW--------------- 610

  Fly   551 AKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLL 615
                              |..|...|||.....:.::.|.::....||:..:...|:|::...|.
Mouse   611 ------------------FVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLT 657

  Fly   616 MEK-PKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVP--TTKENEADED 677
            :.: ..:|::|.||                                .|.|.:|  |..::...:.
Mouse   658 ITRIESSIQSLQDL--------------------------------SKQTDIPYGTVLDSAVYQH 690

  Fly   678 EPVDP-NPVSTDP--AKSYRDIVHSHETGAHAKDNAASNWLDPETGL--LRHLGFAFHVDVAAAY 737
            ..:.. ||...|.  ::.:|.|..|        :.:.:|.|:.:.|:  :::..:||..| ||..
Mouse   691 VRMKGLNPFERDSMYSQMWRMINRS--------NGSENNVLESQAGIQKVKYGNYAFVWD-AAVL 746

  Fly   738 KIIAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRK 801
            :.:|  .::.| |....|......:...| :|..||.|.|.|..:..:.::|.:....:.|..:.
Mouse   747 EYVA--INDPD-CSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKN 808

  Fly   802 PPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYS-------KWHNR 850
            ..|       ||:..:|.......:.:.|.|....||...|:.|       .|.:|
Mouse   809 GQC-------DLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	28/116 (24%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	50/273 (18%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		5/13 (38%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	24/125 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	85/495 (17%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740