Protein Alignment Ir64a and Gria4

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: XP_006509904.1
• Gene: Gria4 / 14802
• MGIID: 95811
• Length: 912
• Species: Mus musculus
• Alignment Length: 696
• Identity: 127/696 - (18%)
• Similarity: 225/696 - (32%)
• Gaps: 213/696 - (30%)

  Fly   214 EEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKR-------MSEAAHY--------TLFD 263
            |.||......|.|..|...|:|    ......::.:::|       .:.||.:        ||..
Mouse   291 ETPPKYTSALTYDGVLVMAETF----RSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQ 351

  Fly   264 VWNPGL-------NYGGHVNLT------------EIGSFTPTEGIQL----HTWFRTTSTVRRRM 305
            |...||       :||..||.|            ::|.:...:.:.|    .|....|:.:..|
Mouse   352 VRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIENR- 415

  Fly   306 DMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWG 370
                     .||||....:..:||...|.|....|....:..:|...:.......:.::
Mouse   416 ---------TVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIA------ 465

  Fly   371 YVKNGRF----------DGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPR 425
            .|.:|::          :||:|.|:..:.:|..||:...|.|.:.||.:....|.....:.:.|:
Mouse   466 IVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 530

  Fly   426 STQKDRIVFLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRH 486
            .::.....||.|...::|:.||    |..|: :|::...:..||
Mouse   531 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEW--------------------- 573

  Fly   487 HYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKA 551
                                            ..||.||.                      ::.
Mouse   574 --------------------------------HTEEPEDG----------------------KEG 584

  Fly   552 KQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLM 616
            ...:.|...|:| .|:.|.:|...|||...|...:|||.:......|:..|...|:|::...|.:
Mouse   585 PSDQPPNEFGIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 648

  Fly   617 EK-PKTIKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVP-----TTKENEA 674
            |: ...|::..||. .:.:..|..|....:::|..:|..|..:::....::.|     ||.|..|
Mouse   649 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVA 713

  Fly   675 DEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKI 739
                     .|.....|                                   |||.::     ..
Mouse   714 ---------RVRKSKGK-----------------------------------FAFLLE-----ST 729

  Fly   740 IAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPP 803
            :.|...::..||..:|......|...: ..|.|.:|..::..:.:::|.|:|....|.|...|..
Mouse   730 MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGE 794

  Fly   804 C-----VKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844
            |     ..|.:||.|  .:..|:....||:....:.:::...|..|
Mouse   795 CGPKDSGSKDKTSAL--SLSNVAGVFYILVGGLGLAMLVALIEFCY 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	24/127 (19%)
		Lig_chan	563..828	CDD:459656	56/277 (20%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	23/112 (21%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	92/522 (18%)