DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and GRIN3A

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	953	Identity:	181/953 - (18%)
Similarity:	310/953 - (32%)	Gaps:	285/953 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVFLPLSCQGLPEHELLELELDYGLAEPQRTSLLQSSLILQFSQDYKHIPRITYFTCQKP---- 65
            ||.| |.| ||    |::||:|              .||:|       |||.|:....:.|
Human   196 LLAF-PQS-QG----EMMELDL--------------VSLVL-------HIPVISIVRHEFPRESQ 233

  Fly    66 ---HLQ--TPNQIPNAAEHRDAFAAK----NFQLIKSLYESELFVRIVLLDVLAQSPTSGRPNRP 121
               |||  ..|.:.:.|:...:....    ||.|:  |.:.:..:...||  |.|:.:...
Human   234 NPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLL--LCQEDWNITDFLL--LTQNNSKFH---- 290

  Fly   122 GNGPTGGFSQTPSQAQSNSEWLEGV-LRMEALRQI--AVVDLACGAVS-RRFLELASAKMLYSEK 182
                .|......:...|..:.|..: :::|:::..  .||...|...| ||..|:.:...:...:
Human   291 ----LGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPE 351

  Fly   183 FHWLL-----IEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGGMNLY 242
            ..|:|     :|:....|........||......|.......::.|........|:..|..:...
Human   352 LRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPST 416

  Fly   243 MN------TELTLAKRMSEAAHYTLFD---------------------VWNPGLNYGGHVNLTEI 280
            ||      |.||..:.:|.....|.|.                     :||...:..|....|.:
Human   417 MNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRL 481

  Fly   281 GSFT-----------PTEGIQLHTWFRTTSTVRRRMD--MQH---------------ARVRCMVV 317
            ||:.           |.:..:..|.|:..|.:..|:.  ::|               |...|:..
Human   482 GSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDP 546

  Fly   318 VTNKNMTGTLMYYLTHTMSGHIDTMNR-----FNFNLLMAVRDMFNWTFVL-----SRTTSWGYV 372
            :||.:.|...::...|:.:..:....:     :..:||..:.:..|:.|.|     .:..:|
Human   547 MTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAW--- 608

  Fly   373 KNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQP 437
            |||.:.|::|.|:|....:..........|.:.||.....:|:....:.| .|.|......|:.|
Human   609 KNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVR-TRDTAAPIGAFMWP 672

  Fly   438 FTNDVWI-LIVGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPV 501
            ....:|: :.|...:..|    |||..|||          .|.|..|
Human   673 LHWTMWLGIFVALHITAV----FLTLYEWK----------SPFGLTP------------------ 705

  Fly   502 RPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKL---NKYIKDRKAKQKKAPERVGLF 563
                         |...:.:.:..|:.::.      ||..|   ...||..|.       ..|.|
Human   706 -------------KGRNRSKVFSFSSALNI------CYALLFGRTVAIKPPKC-------WTGRF 744

  Fly   564 LESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSDL 628
            |.::.   .|.|.                       ||: ..|:|::...::.||
Human   745 LMNLW---AIFCM-----------------------FCL-STYTANLAAVMVGEK---------- 772

  Fly   629 VHSSLKVGMEDILY---NRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPV---ST 687
            ::..|. |:.|...   ::.:...|....|.|.|.::  |.|...|.....:.|..|:.|   ..
Human   773 IYEELS-GIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEMHEYMRRYNVPATPDGVEYLKN 834

  Fly   688 DPAKSYRDIVHSHETGAHAKDNAASNW---LDPETGLLRHLGFAFHVDVAAAYKIIAETFSEQDI 749
            ||.|          ..|...|.|..::   :|.:..||. :|..|.::   .|.|
Human   835 DPEK----------LDAFIMDKALLDYEVSIDADCKLLT-VGKPFAIE---GYGI---------- 875

  Fly   750 CDLTEVSMFPPQKTVSIMQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPCVKK--IETSD 812
                   ..||         |||:...||..:.:....|.:....:.|: |..||.|:  ..|..
Human   876 -------GLPP---------NSPLTANISELISQYKSHGFMDMLHDKWY-RVVPCGKRSFAVTET 923

  Fly   813 LHVDMDTVSSALLILLFSYAITLM-ILGTEILYSKWHNRIQLK 854
            |.:.:...|...::|...:.:::: .:|..|:|.....||:.|
Human   924 LQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNK 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	26/119 (22%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	52/275 (19%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	67/339 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	63/311 (20%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	95/537 (18%)
		Lig_chan	676..942	CDD:278489	74/404 (18%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		6/16 (38%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830