DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and grin3bb

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	962	Identity:	180/962 - (18%)
Similarity:	301/962 - (31%)	Gaps:	328/962 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LAEPQRTSLLQSSLI-LQFSQDYKHIPRITYFTCQKP-------HLQTPNQIPNAAEHRDAFAAK 86
            ||.||    .|..:: ::|...:..||.|:.....:|       |||...:||.:.......|.
Zfish   118 LAFPQ----TQEEIVQMEFMSSFLEIPFISIIEHGEPLKTQNRFHLQMTTRIPPSGLVELLLAV- 177

  Fly    87 NFQLIKSLYESELFV------RIVLLDVLAQSPTSGRPNRPGNGPTG-------GFSQTPSQAQS 138
               |.:|.:|..:.|      ...|||:|...      .|.|.||:.       ..|.:.::..:
Zfish   178 ---LQRSGWEESMAVLCHGWEDAGLLDLLKLQ------GRFGWGPSQWHLRAALNLSHSTARMAN 233

  Fly   139 NSEWLEGVLRMEALRQIAVV----DLAC-GAVSRRFLELASAKMLYSEKFHWLLIEDFAWHGRTQ 198
            .|::|.....::.....:|:    |..| .:|.|...:|.    |.....||::     .|..:.
Zfish   234 ISDFLSEHFNLDHSPPASVLLFGADPECASSVLRSAHDLG----LTLPTVHWIM-----GHPLSP 289

  Fly   199 TAEGS-----GKRDDGEMEEE-----------------------EPPGQQIQ-------ATDDED 228
            .|..|     |....||::.:                       .|....||       ..:..:
Zfish   290 DALHSIGLPLGLLAYGEVDHKPLDFYISDALQLINRAVTAATVVRPDLALIQNMVNCFDKPNKHE 354

  Fly   229 LPS----IESFLGGMNLYMNTELTLAKRMSEAAHYT-LFDVWN-------------PGLNYGGHV 275
            |||    |..||...:....|...:.:|.....|.: ...:|:             .|...||.:
Zfish   355 LPSSGQYIARFLSNTSFVGLTGPVIVQRNLSRVHTSHKVHIWSLRRDAVGQPTWVTVGSWEGGRL 419

  Fly   276 NLTEIGSF---TP---TEGIQL----HTWFRTTSTVRRRMDMQHARVRCMVVV------------ 318
            |:.|.|.:   :|   ||| |:    ..|       |....:..:|:|.:.:|
Zfish   420 NVEEQGLWQGSSPRQRTEG-QMGREGRRW-------RAGFPVSGSRLRVVTLVEHPFVFTREVDE 476

  Fly   319 ------------TNKNMTGTLMYYLTHTMSGH----------------IDTMNRFNFNLLMAVRD 355
                        ...|.:.||.:.......|:                ||.:.:.:       .|
Zfish   477 DGNCPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLS-------ED 534

  Fly   356 M-FNWTFVLSRTTSWGYVKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCF 419
            | |.:...:.....:|.||.|::.|::|.|:....|:..........|.|.||.....:|:....
Zfish   535 MNFEFDLYIVGDGKYGAVKGGQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSLGI 599

  Fly   420 IFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFLTTIEWK----LVPHDGSALIKPKG 480
            :.| .:.|......|:.|..   |.:.:|..|.......|||..|||    :.||
Zfish   600 LVR-SKDTAAPIGAFMWPLH---WSMWMGIFVALHITALFLTLYEWKSPFGMTPH---------- 650

  Fly   481 GAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKY 545
                                           .:.:|  |...|..:..:        ||.
Zfish   651 -------------------------------GRNRV--KVFSYSSALNL--------CYA----- 669

  Fly   546 IKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASI 610
            |...:....|.|:                |.          :||.::....:|...:...|:|::
Zfish   670 ILFGRTVSSKTPK----------------CW----------TGRFLMNLWAIFCLLVLSSYTANL 708

  Fly   611 VGTLLMEKPKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEAD 675
            ...::.|  ||.:.:|.:..:.|....:...:.      |....|.|.|.||  |.|...|....
Zfish   709 AAVMVGE--KTFEEVSGIHDAKLHHPSQGFRFG------TVRESSAEDYMKK--SFPEMHEYMRK 763

  Fly   676 EDEPVDPNPVS---TDPAKSYRDIVHSHETGAHAKDNAASNW---LDPETGLLRHLGFAFHVDVA 734
            .:||..|:.|:   |||.          :..|...|.|..::   :|.:..||. :|..|.::
Zfish   764 FNEPTTPDGVATLKTDPP----------QLDAFIMDKALLDYEVSIDADCKLLT-VGKPFAIE-- 815

  Fly   735 AAYKIIAETFSEQDICDLTEVSMFPPQKTVSIMQKNSPMRKVISYGLRRVTETGILTYHFNVWHS 799
             .|.|                          .:.:|||:...||..:.|....|.:....:.|:
Zfish   816 -GYGI--------------------------GLPQNSPLTSNISEFVSRYKSDGYMDMLHDKWY- 852

  Fly   800 RKPPCVKKI----ET--------SDLHVDMDT-VSSALLILLFSYAITLMIL 838
            :..||.|::    ||        |.|.|.:.. |:.|||.|...:|...::|
Zfish   853 KVVPCGKRVFAVTETLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAFYRLVL 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	26/114 (23%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	57/283 (20%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	65/332 (20%)
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	92/537 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840