DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir64a and LOC100149482

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	661	Identity:	114/661 - (17%)
Similarity:	215/661 - (32%)	Gaps:	203/661 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 LGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLTEIGSFTPTEG------------ 288
            |||.:...:.|..||               ||.|         ::.|:||..|
Zfish   372 LGGRDYSFSNEGYLA---------------NPFL---------DVISYTPGSGWEDVGWWENGVL 412

  Fly   289 -IQLHTWFRTTSTVRRRMDMQHARV-----RCMVVVTNKN-MTGTLM------------YYLTHT 334
             ::...|.|....::...|.||.||     |..|:|...: .:||.:            ..|...
Zfish   413 RLRYPAWSRYGPFLQPPDDAQHLRVVTLEERPFVIVELADAASGTCIRDSVPCRRPLNASALQEG 477

  Fly   335 MSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVK--NGRFDGMIGALIRNETDIGGAPIF 397
            ::........|..::|..:..:..:|:.|...|:..:.|  :|.::||:|.::....|:....:.
Zfish   478 VAPVKQCCKGFCIDILKRLARIVGFTYDLYLVTNGKHGKKIDGVWNGMVGEVVYKRADMAIGSLT 542

  Fly   398 YWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILI-VGC---GVLTVFILW 458
            ...||.:.:|.:.....:....:......|.... .||:|::..||::: |.|   ..:||||..
Zfish   543 INEERSEVVDFSVPFVETGISVMVSRSNGTVSPS-AFLEPYSPAVWVMMFVMCLTVVAVTVFIFE 606

  Fly   459 FLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEY 523
            |.:.:.:......|    |..||:                         ...:.|
Zfish   607 FFSPVGYNRSLQSG----KKAGGS-------------------------KFTIGK---------- 632

  Fly   524 EDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSG 588
                     ::|                           .|.:::|...:..:...|     .:.
Zfish   633 ---------SIW---------------------------LLWALVFNNSVPVENPKG-----TTS 656

  Fly   589 RCIVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKDP 653
            :.:|:....|:......|:|::...::.|  :.|.|:|         |:.|     ..|.|
Zfish   657 KIMVLVWAFFAVIFLASYTANLAAFMIQE--EYIDTVS---------GLSD-----KKFQH---- 701

  Fly   654 VSMELYAK-KITSVP--TTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWL 715
             ..|.|.. |..:||  :|::|.......:....|..: .||..|.:...:||.          |
Zfish   702 -PTEQYPPLKFGTVPNGSTEKNIRSNYPDMHQYMVKYN-QKSVEDAISHLKTGK----------L 754

  Fly   716 DPETGLLRHLGFAFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSIMQKNSPMRKVISYG 780
            |           ||..| ||....:|.......:..:....:|........:.|||..::.:...
Zfish   755 D-----------AFIYD-AAVLNYMARKDEGCKVMTIGSGKVFATTGYGIALIKNSRWKRPLDLA 807

  Fly   781 LRRVTETGILTYHFNVW-----HSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGT 840
            |.::.....:.....:|     |:      .|||.....:|:|.::....:||.:..::|::...
Zfish   808 LLQLVGDDEIEMLERLWLSGICHN------DKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAW 866

  Fly   841 E-ILYSKWHNR 850
            | ::|  |..|
Zfish   867 EHLVY--WRLR 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	25/119 (21%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	48/272 (18%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	14/72 (19%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	85/522 (16%)
		HisJ	<487..>570	CDD:223904	14/82 (17%)
		Lig_chan	585..857	CDD:278489	65/401 (16%)
		NMDAR2_C	868..>900	CDD:287527	3/10 (30%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830