Protein Alignment Ir64a and grin2ca

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 623
• Identity: 116/623 - (18%)
• Similarity: 202/623 - (32%)
• Gaps: 224/623 - (35%)

  Fly   294 WFRTTSTVRRRMDMQHARV-----RCMVVVTNKN-MTGTLMYYL---------THTMSGH----- 338
            |.|..:.:....|.:|..|     |..|:|...: :|||.:...         |.|:.||
Zfish   396 WPRYGTFLEPVSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHTEPYT 460

  Fly   339 --------IDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVKNGRFDGMIGALIRNETDIGGAP 395
                    ||.:.:.:.|:      .|::...|......|.:..|.::||||.:.....|:....
Zfish   461 KLCCKGFCIDILKKLSRNI------KFSYDLYLVTNGKHGKLVRGIWNGMIGEVFYKRADMAIGS 519

  Fly   396 IFYWLERHKWID-------------VAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILI- 446
            :....||.:.||             ||..:.:..|.              .||:|::..||:::
Zfish   520 LTINEERSEIIDFSVPFVETGISVMVARSNGTVSPS--------------AFLEPYSPAVWVMMF 570

  Fly   447 VGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVV 511
            |.|  |||                                                  .||:|.|
Zfish   571 VMC--LTV--------------------------------------------------VAVTVFV 583

  Fly   512 SKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPE-RVGLFLESVLFFVGIIC 575
                       :|..:|:.           .|:.:.  .||....|. .:|   :||....||:
Zfish   584 -----------FEYCSPVG-----------YNRSLV--SAKDPGGPTFTIG---KSVWLLWGIV- 620

  Fly   576 QQGLGFSTSF-------VSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSDLVHSSL 633
                 |:.|.       .:.:.:|:....|:......|:|::...::.|  :.|.|:|
Zfish   621 -----FNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQE--QYIDTVS------- 671

  Fly   634 KVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEP----VDPNPVSTDPAKSYR 694
              |:.|                     ||.       :...|:..|    ..||..:....:|..
Zfish   672 --GLSD---------------------KKF-------QKPQDQYPPFRFGTVPNGSTERNIRSNY 706

  Fly   695 DIVHSHETGAHAKD-NAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFSEQDICDLTEV--- 755
            ..:|||....:.|. ..|.|.|  :||.|.    ||..|.|    ::.....:.:.|.|..:
Zfish   707 PEMHSHMVKYNQKGVEDALNSL--KTGKLD----AFIYDAA----VLNYMAGKDEGCKLVTIGSG 761

  Fly   756 SMFPPQKTVSIMQKNSPMRKVISYGLRRVTETGILTYHFNVW-----HSRKPPCVKKIETSDLHV 815
            .:|........:||.|..::.|...|.:....|.......||     .:.|    |::.:|.|
Zfish   762 KVFATTGYGIALQKESRWKRPIDLALLQFLADGDTQKLQTVWLTGICRNEK----KEVMSSKL-- 820

  Fly   816 DMDTVSSALLILLFSYAITLMILGTE-ILYSKWHNRIQ 852
            |:|.::....:||.:..::|::...| :||.|..:.::
Zfish   821 DIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVR 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	26/127 (20%)
		Lig_chan	563..828	CDD:459656	54/284 (19%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	100/554 (18%)
		NMDAR2_C	847..>938	CDD:463148	3/12 (25%)