DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Membrin and GOSR2

DIOPT Version :9

Sequence 1:	NP_647960.1	Gene:	Membrin / 38614	FlyBaseID:	FBgn0260856	Length:	216	Species:	Drosophila melanogaster
Sequence 2:	NP_001308062.1	Gene:	GOSR2 / 9570	HGNCID:	4431	Length:	257	Species:	Homo sapiens

Alignment Length:	197	Identity:	83/197 - (42%)
Similarity:	123/197 - (62%)	Gaps:	3/197 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESLYHQTNNVVKDIERDFQRLSQLSAQESLDVENGIQLKITQANANCDRLDVLLYKVPPSQRQS 65
            |:.|:.||:..|.:|:....||.....|....|||.||..|.|..:..:||::|..|.||::||:
Human     1 MDPLFQQTHKQVHEIQSCMGRLETADKQSVHIVENEIQASIDQIFSRLERLEILSSKEPPNKRQN 65

  Fly    66 SKLRVDQLKYDLRHLQTSLQTARERRQRRMQEISEREQLLNHRFTANSAQPEETRLQLDYELQHH 130
            ::|||||||||::||||:|:..:.||..|.|:..:||:||:..||.|.:   :|.:.:|..||.:
Human    66 ARLRVDQLKYDVQHLQTALRNFQHRRHAREQQERQREELLSRTFTTNDS---DTTIPMDESLQFN 127

  Fly   131 TQLGNAHRGVDDMIASGSGILESLISQRMTLGGAHKRIQAIGSTLGLSNHTMKLIERRLVEDRRI 195
            :.|...|.|:||:|..|..||:.|.:||:||.|..|:|..|.:.|||||..|:|||:|..:|:..
Human   128 SSLQKVHNGMDDLILDGHNILDGLRTQRLTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYF 192

  Fly   196 FI 197
            .|
Human   193 MI 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Membrin	NP_647960.1	SNARE_GS27	124..188	CDD:277216	30/63 (48%)
GOSR2	NP_001308062.1	IxM motif, signal for cargo packaging into COPII-coated vesicles. /evidence=ECO:0000269\|PubMed:18843296	118..120		0/1 (0%)
GOSR2	NP_001308062.1	SNARE_GS27	120..185	CDD:277216	30/64 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7461
eggNOG	1	0.900	-	-		E1_KOG3251
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37907
Inparanoid	1	1.050	169	1.000	Inparanoid score	I4146
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55230
OrthoDB	1	1.010	-	-		D1139640at2759
OrthoFinder	1	1.000	-	-		FOG0003803
OrthoInspector	1	1.000	-	-		oto91262
orthoMCL	1	0.900	-	-		OOG6_102735
Panther	1	1.100	-	-	LDO	PTHR21230
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4591
SonicParanoid	1	1.000	-	-		X4845
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870