DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyt-c1 and CYT1

DIOPT Version :9

Sequence 1:	NP_001246637.1	Gene:	Cyt-c1 / 38612	FlyBaseID:	FBgn0035600	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_014708.1	Gene:	CYT1 / 854231	SGDID:	S000005591	Length:	309	Species:	Saccharomyces cerevisiae

Alignment Length:	287	Identity:	155/287 - (54%)
Similarity:	203/287 - (70%)	Gaps:	13/287 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SSAGSWASGNKKLIGALGAITGGVGA-------LIYA---LEQSVQASGGEVHSPAQLWNHKGLF 83
            |:|...||.:.||...|  :|.||.|       |:||   ..:::.|:...:|:||..|:|.|.|
Yeast    20 STATGAASKSGKLTQKL--VTAGVAAAGITASTLLYADSLTAEAMTAAEHGLHAPAYAWSHNGPF 82

  Fly    84 DALDHQSVRRGYEVYKQVCSACHSMQYIAYRNLVGVTHTEAEAKAEAEQITVKDGPDDTGNYYTR 148
            :..||.|:||||:||::||:||||:..:|:|.||||:||..|.:..||:....|.||:.||...|
Yeast    83 ETFDHASIRRGYQVYREVCAACHSLDRVAWRTLVGVSHTNEEVRNMAEEFEYDDEPDEQGNPKKR 147

  Fly   149 PGKLSDYFPSPYPNEEAARAANNGAYPPDLSYIVSARKGGEDYIFSLLTGYHD-APAGVVLREGQ 212
            |||||||.|.|||||:||||||.||.|||||.||.||.||.||||||||||.| .||||.|..|.
Yeast   148 PGKLSDYIPGPYPNEQAARAANQGALPPDLSLIVKARHGGCDYIFSLLTGYPDEPPAGVALPPGS 212

  Fly   213 YFNPYFPGGAISMAQVLYNEVIEYEDGTPPTQSQLAKDVATFLKWTSEPEHDDRKQLLIKVIGIL 277
            .:|||||||:|:||:||:::::|||||||.|.||:||||.|||.|.:|||||:||:|.:|.:.||
Yeast   213 NYNPYFPGGSIAMARVLFDDMVEYEDGTPATTSQMAKDVTTFLNWCAEPEHDERKRLGLKTVIIL 277

  Fly   278 GFLTVISYYIKRHKWSSLKSRKIVFVP 304
            ..|.::|.::|:.||:.:|:||.||.|
Yeast   278 SSLYLLSIWVKKFKWAGIKTRKFVFNP 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyt-c1	NP_001246637.1	CYT1	69..296	CDD:225413	134/227 (59%)
Cyt-c1	NP_001246637.1	Cytochrom_C1	77..295	CDD:280350	131/218 (60%)
CYT1	NP_014708.1	Cytochrom_C1	76..295	CDD:396646	131/218 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345191
Domainoid	1	1.000	284	1.000	Domainoid score	I252
eggNOG	1	0.900	-	-		E1_COG2857
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55617
Inparanoid	1	1.050	309	1.000	Inparanoid score	I478
Isobase	1	0.950	-	0	Normalized mean entropy	S421
OMA	1	1.010	-	-		QHG54185
OrthoFinder	1	1.000	-	-		FOG0003553
OrthoInspector	1	1.000	-	-		otm46903
orthoMCL	1	0.900	-	-		OOG6_102032
Panther	1	1.100	-	-	LDO	PTHR10266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R278
SonicParanoid	1	1.000	-	-		X2430
TreeFam	1	0.960	-	-
	16	15.740