DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyt-c1 and CYC1

DIOPT Version :9

Sequence 1:	NP_001246637.1	Gene:	Cyt-c1 / 38612	FlyBaseID:	FBgn0035600	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	XP_016868591.1	Gene:	CYC1 / 1537	HGNCID:	2579	Length:	357	Species:	Homo sapiens

Alignment Length:	255	Identity:	149/255 - (58%)
Similarity:	189/255 - (74%)	Gaps:	3/255 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LIGALGAITGGVGALIYALEQSVQASGGEVHSPAQLWNHKGLFDALDHQSVRRGYEVYKQVCSAC 105
            ::.|||.:..|...|..||..:|.||..|:|.|:..|:|:||..:|||.|:|||::||||||::|
Human     1 MLSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASC 65

  Fly   106 HSMQYIAYRNLVGVTHTEAEAKAEAEQITVKDGPDDTGNYYTRPGKLSDYFPSPYPNEEAARAAN 170
            |||.::|||:||||.:||.|||..|.::.|:|||::.|..:.|||||.||||.||||.|||||||
Human    66 HSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAAN 130

  Fly   171 NGAYPPDLSYIVSARKGGEDYIFSLLTGYHDAPAGVVLREGQYFNPYFPGGAISMAQVLYNEVIE 235
            |||.||||||||.||.|||||:|||||||.:.|.||.||||.||||||||.||:||..:|.:|:|
Human   131 NGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLE 195

  Fly   236 YEDGTPPTQSQLAKDVATFLKWTSEPEHDDRKQLLIKVIGILGFLTVISYYIKRHKWSSL 295
            ::||||.|.||:||||.|||:|.||||||.||::.:||.|:.|.   ..|..:...|:.|
Human   196 FDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKVKGLGGH---GGYQRRAGSWAGL 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyt-c1	NP_001246637.1	CYT1	69..296	CDD:225413	139/227 (61%)
Cyt-c1	NP_001246637.1	Cytochrom_C1	77..295	CDD:280350	135/217 (62%)
CYC1	XP_016868591.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155017
Domainoid	1	1.000	311	1.000	Domainoid score	I1319
eggNOG	1	0.900	-	-		E1_COG2857
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55617
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2251
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54185
OrthoDB	1	1.010	-	-		D439021at33208
OrthoFinder	1	1.000	-	-		FOG0003553
OrthoInspector	1	1.000	-	-		otm41828
orthoMCL	1	0.900	-	-		OOG6_102032
Panther	1	1.100	-	-	LDO	PTHR10266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R278
SonicParanoid	1	1.000	-	-		X2430
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800