Protein Alignment Klp64D and KIF20B

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001271188.1
• Gene: KIF20B / 9585
• HGNCID: 7212
• Length: 1820
• Species: Homo sapiens
• Alignment Length: 828
• Identity: 188/828 - (22%)
• Similarity: 350/828 - (42%)
• Gaps: 217/828 - (26%)

  Fly     2 PQEEANAGTTAQLDDEIENVRVVVRTRPMDKNEL---SAGALSAISVDKINRAITVMKPNA---- 59
            |..|||:      .:..:.::|.:|.||..::|.   |.|.:..:.    ::.:.:.:|..
Human    46 PNTEANS------FESKDYLQVCLRIRPFTQSEKELESEGCVHILD----SQTVVLKEPQCILGR 100

  Fly    60 ----TANEPPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGN 120
                ::.:..:.:.|..||...:.|.:.:.......|..:|:|.:..|..||.|.:|||||..|
Human   101 LSEKSSGQMAQKFSFSKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQG- 164

  Fly   121 PDSPQTKGIIPNAFAHIFG---------------------HIAKAKENQ---------------- 148
              :.:..||:|.....:|.                     .::..:|.:
Human   165 --TEENIGILPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVT 227

  Fly   149 ----------------------------------------KFLVRVSYMEIYNEEVRDLLGKDVG 173
                                                    ||.|.||:.|||||.:.||.   |.
Human   228 VHNDSDDTLYGSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLF---VP 289

  Fly   174 KSLEVKERPDIGV--------FVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAI 230
            .|.:.::|..:.:        |:|||....|.::.:...:::||.|:::|..||:|..|||||:|
Human   290 VSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSI 354

  Fly   231 FSI---TVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVIS 292
            |::   .:|.||:.    :.:|:.:|.|.|||||||..|||..|:||:|...||.||..||..|:
Human   355 FTVKILQIEDSEMS----RVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCIN 415

  Fly   293 ALVDGKST----HIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKN-- 351
            .|.:.:.:    |:|:|.||||...|....|..|..|...||.....|.||::.|::::.|:.
Human   416 VLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVC 480

  Fly   352 IQNRMHINEEPKDALLRHFQE---------EIARLRK----------QLEEGDSLEEEPPSSEE- 396
            :.:.::.::|.....::..|:         :|..:::          .|.|.:.|.||..::||
Human   481 VPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEET 545

  Fly   397 ---EEDTADDELEAPLEIELESSTIQAVEKKPK--------------KKREKTDAE---KEELAK 441
               |....|::|:..||   |:....:.|:|.|              :|:||...|   :||:.:
Human   546 QNVETKLLDEDLDKTLE---ENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQ 607

  Fly   442 RKNEH--QKEIEHAKT---EQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEK 501
            ...::  |:|.:..:|   |:|.|..   :.|.::.: .::|:.|..|:|...:...|...:.|:
Human   608 EFTQYWAQREADFKETLLQEREILEE---NAERRLAI-FKDLVGKCDTREEAAKDICATKVETEE 668

  Fly   502 SE-----EALKQTLQQKATE---RIDIEERY-STL---QDASTGITKKIHRVMQMLMGVKSELAD 554
            :.     |.:..:||....:   :.:|...| ::|   |:|:..:..|.:::...|...|.||..
Human   669 THNYVGFEDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIK 733

  Fly   555 QQQE---HQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNED-IGEWQLKCVA 615
            .::|   .:.|.:.:.:.:.:.::::    :..|..: ||..::|:|    .|| |.|:|
Human   734 TKEELKKRENESDSLIQELETSNKKI----ITQNQRI-KELINIIDQ----KEDTINEFQ----- 784

  Fly   616 YTGNNMRKHISAHKTSGKEPDFLDLSHVYLSYN---TDGVSNPMRSKS 660
                |::.|:   :.:.|..|..|.|.:.::..   .:.|..|..|||
Human   785 ----NLKSHM---ENTFKCNDKADTSSLIINNKLICNETVEVPKDSKS 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	110/437 (25%)
		Smc	<433..>578	CDD:440809	31/167 (19%)
KIF20B	NP_001271188.1	KISc_KIF23_like	57..477	CDD:276819	109/433 (25%)
		RBD_KIF20B	600..654	CDD:409644	12/57 (21%)
		Mplasa_alph_rch	740..1350	CDD:275316	22/107 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	829..866
		Necessary and sufficient for interaction with SHTN1. /evidence=ECO:0000250|UniProtKB:Q80WE4	1050..1107
		SMC_prok_B	<1077..1381	CDD:274008
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1247..1275
		Smc	<1280..>1583	CDD:440809
		PTZ00108	<1501..1792	CDD:240271
		Interaction with PIN1. /evidence=ECO:0000269|PubMed:11470801	1560..1820
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1760..1781