Protein Alignment Klp64D and KIF3B

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_004789.1
• Gene: KIF3B / 9371
• HGNCID: 6320
• Length: 747
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 307/639 - (48%)
• Similarity: 423/639 - (66%)
• Gaps: 44/639 - (6%)

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |:||||||.|||:..|.:|.....:.||.....::|..|..||:|.|||:.||.|:|..:.|.:|
Human     8 ESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFEL 72

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:|.||:||.||:|:||||.|||||||||||||.|....|:.:|:|||:|.|||.||::: :||
Human    73 YDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRS-QNQ 136

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            ::|||.||:|||.||:||||.||..|.||:|||||.||:|||||.:|..:..::|::|.:||:||
Human   137 QYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNR 201

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT 278
            :||||.||:.||||||||.||:|.||:|.....|:|:|||.||||||||||:||.|.|:||||||
Human   202 SVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEAT 266

  Fly   279 KINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTL 343
            |||||||.|||||||||||||||||||:||||||||||||||:||||.|.:.||..|..||::||
Human   267 KINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTL 331

  Fly   344 RYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEE---------------------GDSL 387
            |||:|||||:|:..:||:|||||||.||||||||:.|||:                     |:..
Human   332 RYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEE 396

  Fly   388 EEEPPSSEEEEDTADD---ELEAPLEIE----LESSTIQAVEKKPKKKREKTDAEKEELAKRKNE 445
            |||....|||.|..||   |.:..||||    :|..::.|             .||..|.|.|.:
Human   397 EEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVA-------------EEKMRLLKEKEK 448

  Fly   446 HQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTL 510
            ..:::...|...|.|..|:.::|.|:||||:|:::....|:.:|||...|:.:.::.|..::|.:
Human   449 KMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQM 513

  Fly   511 QQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSR 575
            :.:..|.::::|.||:||......|||:.::...|..||:|:.|.|:||.:|::.:.:....|:|
Human   514 ESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTR 578

  Fly   576 ELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNN--MRKHISA 627
            ||.|..|::.:::|.|.:|.|.....::|:...|:|..:....|.  |::.:||
Human   579 ELKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKLHPITRLENQQMMKRPVSA 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	209/332 (63%)
		Smc	<433..>578	CDD:440809	44/144 (31%)
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	209/332 (63%)
		Smc	<355..>581	CDD:440809	74/238 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..412		8/37 (22%)
		Globular	580..747		14/53 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	699..747