Protein Alignment Klp64D and CIN8

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_010853.2
• Gene: CIN8 / 856648
• SGDID: S000000787
• Length: 1000
• Species: Saccharomyces cerevisiae
• Alignment Length: 802
• Identity: 217/802 - (27%)
• Similarity: 347/802 - (43%)
• Gaps: 195/802 - (24%)

  Fly     1 MPQEEANAGTTAQ----------------LDDEIENVRVVVRTRPMDKNELSAGALSAISVDKI- 48
            ||.|..|.|....                :.:|..|:.|.||.|..::.|:|..:...::|..|
Yeast     1 MPAENQNTGQDRSSNSISKNGNSQVGCHTVPNEELNITVAVRCRGRNEREISMKSSVVVNVPDIT 65

  Fly    49 -NRAI---TVMKPNATANEPPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQT 109
             ::.|   |......||....|.|..|.||..|::|..::.:.|.|:....::|||.|:|.||.|
Yeast    66 GSKEISINTTGDTGITAQMNAKRYTVDKVFGPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMT 130

  Fly   110 GTGKTYTMSG-----NPDSPQTKGIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLG 169
            .|||||||:|     |.:.....||||.....:|..: :.::|. ::|:.|::|:||||::|||.
Yeast   131 STGKTYTMTGDEKLYNGELSDAAGIIPRVLLKLFDTL-ELQQND-YVVKCSFIELYNEELKDLLD 193

  Fly   170 KD---------------------------------------------------------VGKSLE 177
            .:                                                         :.|.|.
Yeast   194 SNSNGSSNTGFDGQFMKKLRIFDSSTANNTTSNSASSSRSNSRNSSPRSLNDLTPKAALLRKRLR 258

  Fly   178 VKERPDI-------------------------------------------------GVFVKDLSG 193
            .|..|:.                                                 |:::::|..
Yeast   259 TKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGIYIQNLQE 323

  Fly   194 YVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDL 258
            :.:.||.:..|:::.|.|:|.|.:||||..|||||.||:||:.:....|    ..|:.|:.||||
Yeast   324 FHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKKHQDE----LFRISKMNLVDL 384

  Fly   259 AGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKT 323
            ||||..:::.|..||.|||..||.||..||.||:|||| ||.|||:|.||||||||||||||:||
Yeast   385 AGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVD-KSGHIPFRESKLTRLLQDSLGGNTKT 448

  Fly   324 VMCATISPADSNYMETISTLRYASRAKNIQNRMHINE-EPKDALLRHFQEEIARLRKQLEEGDSL 387
            .:.||||||.....||.|||.|||:||||:|:..:.. ..||.|:::...|:|:::..|....|.
Yeast   449 ALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLGSFIMKDILVKNITMELAKIKSDLLSTKSK 513

  Fly   388 EEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEIEH 452
            |....|.:..::         |..:|||...:..|  .|::.|...::...|.|.|.:.::.|:.
Yeast   514 EGIYMSQDHYKN---------LNSDLESYKNEVQE--CKREIESLTSKNALLVKDKLKSKETIQS 567

  Fly   453 AKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATER 517
            ...:.|:|:..:..|..:        |:|....|:.:.....:|   :|..|.::..|.......
Yeast   568 QNCQIESLKTTIDHLRAQ--------LDKQHKTEIEISDFNNKL---QKLTEVMQMALHDYKKRE 621

  Fly   518 IDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELAL--- 579
            :|:.:::      ...|||:|.::...|.   .:|...|||...::..|..|:..:..|:..
Yeast   622 LDLNQKF------EMHITKEIKKLKSTLF---LQLNTMQQESILQETNIQPNLDMIKNEVLTLMR 677

  Fly   580 -----CELVLNSYV-------PKEYQSMINQ-------YTHWNEDIGEWQLKCVAYTGNNMRKHI 625
                 .||:....|       ||.:..:|.:       :..:.::|.| .|..::...|||::::
Yeast   678 TMQEKAELMYKDCVKKILNESPKFFNVVIEKIDIIRVDFQKFYKNIAE-NLSDISEENNNMKQYL 741

  Fly   626 SAHKTSGKEPDFLDLSHVYLSY 647
            ..|.......:.|: .||..:|
Yeast   742 KNHFFKNNHQELLN-RHVDSTY 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	148/448 (33%)
		Smc	<433..>578	CDD:440809	27/144 (19%)
CIN8	NP_010853.2	KISc_BimC_Eg5	34..486	CDD:276815	151/458 (33%)
		235kDa-fam	<520..978	CDD:130673	51/276 (18%)