DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and CIN8

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_010853.2	Gene:	CIN8 / 856648	SGDID:	S000000787	Length:	1000	Species:	Saccharomyces cerevisiae

Alignment Length:	802	Identity:	217/802 - (27%)
Similarity:	347/802 - (43%)	Gaps:	195/802 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPQEEANAGTTAQ----------------LDDEIENVRVVVRTRPMDKNELSAGALSAISVDKI- 48
            ||.|..|.|....                :.:|..|:.|.||.|..::.|:|..:...::|..|
Yeast     1 MPAENQNTGQDRSSNSISKNGNSQVGCHTVPNEELNITVAVRCRGRNEREISMKSSVVVNVPDIT 65

  Fly    49 -NRAI---TVMKPNATANEPPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQT 109
             ::.|   |......||....|.|..|.||..|::|..::.:.|.|:....::|||.|:|.||.|
Yeast    66 GSKEISINTTGDTGITAQMNAKRYTVDKVFGPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMT 130

  Fly   110 GTGKTYTMSG-----NPDSPQTKGIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLG 169
            .|||||||:|     |.:.....||||.....:|..: :.::|. ::|:.|::|:||||::|||.
Yeast   131 STGKTYTMTGDEKLYNGELSDAAGIIPRVLLKLFDTL-ELQQND-YVVKCSFIELYNEELKDLLD 193

  Fly   170 KD---------------------------------------------------------VGKSLE 177
            .:                                                         :.|.|.
Yeast   194 SNSNGSSNTGFDGQFMKKLRIFDSSTANNTTSNSASSSRSNSRNSSPRSLNDLTPKAALLRKRLR 258

  Fly   178 VKERPDI-------------------------------------------------GVFVKDLSG 193
            .|..|:.                                                 |:::::|..
Yeast   259 TKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGIYIQNLQE 323

  Fly   194 YVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDL 258
            :.:.||.:..|:::.|.|:|.|.:||||..|||||.||:||:.:....|    ..|:.|:.||||
Yeast   324 FHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKKHQDE----LFRISKMNLVDL 384

  Fly   259 AGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKT 323
            ||||..:::.|..||.|||..||.||..||.||:|||| ||.|||:|.||||||||||||||:||
Yeast   385 AGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVD-KSGHIPFRESKLTRLLQDSLGGNTKT 448

  Fly   324 VMCATISPADSNYMETISTLRYASRAKNIQNRMHINE-EPKDALLRHFQEEIARLRKQLEEGDSL 387
            .:.||||||.....||.|||.|||:||||:|:..:.. ..||.|:::...|:|:::..|....|.
Yeast   449 ALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLGSFIMKDILVKNITMELAKIKSDLLSTKSK 513

  Fly   388 EEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEIEH 452
            |....|.:..::         |..:|||...:..|  .|::.|...::...|.|.|.:.::.|:.
Yeast   514 EGIYMSQDHYKN---------LNSDLESYKNEVQE--CKREIESLTSKNALLVKDKLKSKETIQS 567

  Fly   453 AKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATER 517
            ...:.|:|:..:..|..:        |:|....|:.:.....:|   :|..|.::..|.......
Yeast   568 QNCQIESLKTTIDHLRAQ--------LDKQHKTEIEISDFNNKL---QKLTEVMQMALHDYKKRE 621

  Fly   518 IDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELAL--- 579
            :|:.:::      ...|||:|.::...|.   .:|...|||...::..|..|:..:..|:..
Yeast   622 LDLNQKF------EMHITKEIKKLKSTLF---LQLNTMQQESILQETNIQPNLDMIKNEVLTLMR 677

  Fly   580 -----CELVLNSYV-------PKEYQSMINQ-------YTHWNEDIGEWQLKCVAYTGNNMRKHI 625
                 .||:....|       ||.:..:|.:       :..:.::|.| .|..::...|||::::
Yeast   678 TMQEKAELMYKDCVKKILNESPKFFNVVIEKIDIIRVDFQKFYKNIAE-NLSDISEENNNMKQYL 741

  Fly   626 SAHKTSGKEPDFLDLSHVYLSY 647
            ..|.......:.|: .||..:|
Yeast   742 KNHFFKNNHQELLN-RHVDSTY 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	148/448 (33%)
		Kinesin	26..352	CDD:278646	145/441 (33%)
		RILP-like	<437..556	CDD:304877	21/118 (18%)
CIN8	NP_010853.2	KISc_BimC_Eg5	34..486	CDD:276815	151/458 (33%)
		Smc	<493..>772	CDD:224117	57/303 (19%)
		CCDC158	677..>928	CDD:318193	17/88 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I592
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001102
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	4.040