DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and SMY1

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_012844.1	Gene:	SMY1 / 853783	SGDID:	S000001562	Length:	656	Species:	Saccharomyces cerevisiae

Alignment Length:	730	Identity:	178/730 - (24%)
Similarity:	311/730 - (42%)	Gaps:	159/730 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QEEANAGTTAQLDDEIE--NVRVVVRTRP---MDKNELSAGALSAISVDKINRAITVMKPN---A 59
            :|::::..:....|..|  ::.|::|..|   :..||      |...:|.....:.....|   .
Yeast     8 KEQSSSSVSLPTLDSSEPCHIEVILRAIPEKGLQNNE------STFKIDPYENTVLFRTNNPLHE 66

  Fly    60 TANEPPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSP 124
            |..|...|:.||.|||..:.|.|:......||::.||.|||||::.||.:.:||:|::.|   |.
Yeast    67 TTKETHSTFQFDKVFDANATQEDVQKFLVHPIINDVLNGYNGTVITYGPSFSGKSYSLIG---SK 128

  Fly   125 QTKGIIPNAFAHIFGHIAKAKENQ--KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVF 187
            :::||:||....:|..:.|.:|.:  .|.|.|...|||.|:..|||       :.:.||..:.:.
Yeast   129 ESEGILPNICKTLFDTLEKNEETKGDSFSVSVLAFEIYMEKTYDLL-------VPLPERKPLKLH 186

  Fly   188 ---------VKDLSGYVVHNADDLEN----IMRLGNKNRAVGATKMNQESSRSHAIFSITVERSE 239
                     :||:....|.:.:||.:    :..:||:......|    |.||||.:|.:.||:..
Yeast   187 RSSSKMDLEIKDICPAHVGSYEDLRSYIQAVQNVGNRMACGDKT----ERSRSHLVFQLHVEQRN 247

  Fly   240 LGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISAL--------VD 296
             .:.|:  ::...|.||||.|:|:..|...|........|:|.|:..|.|.:.:|        ..
Yeast   248 -RKDDI--LKNSSLYLVDLHGAEKFDKRTESTLSQDALKKLNQSIEALKNTVRSLSMKERDSAYS 309

  Fly   297 GKSTH-IPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHIN- 359
            .|.:| ..||.|:||.:|:||||||.||.:..|...  ||...|:|||.:....:.|.|::..|
Yeast   310 AKGSHSSAYRESQLTEVLKDSLGGNRKTKVILTCFL--SNVPTTLSTLEFGDSIRQINNKVTDNT 372

  Fly   360 -----EEPKDALLR-------HFQEEIARLRKQLEEGDSLEEEP-PSSEEE---EDTADDELEAP 408
                 ::..|..::       ::..:|..|:.:::...||..:. |..:|:   |:|..:.::
Yeast   373 TGLNLKKKMDLFIQDMKIKDDNYVAQINILKAEIDSLKSLHNKSLPEDDEKKMLENTKKENIK-- 435

  Fly   409 LEIELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEIEHAKTEQETLRNKLVSLEGKILV 473
            |:::|:|.|........:....:.|.|..|:..::.|...::|.:...|....:||
Yeast   436 LKLQLDSITQLLSSSTNEDPNNRIDEEVSEILTKRCEQIAQLELSFDRQMNSNSKL--------- 491

  Fly   474 GGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKI 538
                      .|||          :::||:|...:::..:..|:|.::|
Yeast   492 ----------QQEL----------EYKKSKEEALESMNVRLLEQIQLQE---------------- 520

  Fly   539 HRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLN-SYVPKEYQSMINQYTHW 602
             |.:|.|:...:.|..:.:.|.:..|...|.|:||  |.::.||.|| |.:|...:..::
Yeast   521 -REIQELLTTNAILKGELETHTKLTETRSERIKSL--ESSVKELSLNKSAIPSPRRGSMS----- 577

  Fly   603 NEDIGEWQLKCVAYTGNNMRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPM-----RSKSAR 662
                        :.:||.|     .|...|.|     :|:...|.||.  |.|:     :..|:.
Yeast   578 ------------SSSGNTM-----LHIEEGSE-----ISNSPWSANTS--SKPLVWGARKVSSSS 618

  Fly   663 PRTSGVPRPTTARRY 677
            ..|:|......||.:
Yeast   619 IATTGSQESFVARPF 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	109/364 (30%)
		Kinesin	26..352	CDD:278646	107/355 (30%)
		RILP-like	<437..556	CDD:304877	19/118 (16%)
SMY1	NP_012844.1	KISc_KHC_KIF5	25..364	CDD:276820	108/363 (30%)
SMY1	NP_012844.1	Smc	<254..568	CDD:224117	87/365 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001102
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910