DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and KIP3

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_011299.1	Gene:	KIP3 / 852655	SGDID:	S000003184	Length:	805	Species:	Saccharomyces cerevisiae

Alignment Length:	789	Identity:	222/789 - (28%)
Similarity:	352/789 - (44%)	Gaps:	193/789 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EANAGTTAQLDDEI--------ENVRVVVRT--------RPMDKNELSAGALSAISVDKINRAIT 53
            :|..|:|....:.:        |.:|.:|..        .|.|:|.|:..:      |::..::.
Yeast    62 DAEEGSTRSKRNSLLRRKVIRPEGIRKIVDCVDDRMLIFDPADRNPLNKVS------DQVLNSMR 120

  Fly    54 VMKPNATA---NEPPKT---------------YYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYN 100
            .....|||   |....|               :.||.:||..|:|..:|.:|..|::|.||:|:|
Yeast   121 ARATKATASSINNSNATNKFSSQRRRHGGEIKFVFDKLFDETSSQARVYKETTSPLLDSVLDGFN 185

  Fly   101 GTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVR 165
            .|:.|||.||.|||||:||.|..|   |||..|...:|..|...|:.:.|.:.:||:|||||.:|
Yeast   186 STVFAYGATGCGKTYTVSGTPSQP---GIIFLAMEELFNKITDLKDEKDFEISLSYLEIYNERIR 247

  Fly   166 DLLGKDV-GKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRL---GNKNRAVGATKMNQESSR 226
            |||..:. .|.|.::|.....:.|.:||   .|:.:.:|::|.|   ||.||....|:.|:.|||
Yeast   248 DLLKPETPSKRLVIREDTQNHIKVANLS---YHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSR 309

  Fly   227 SHAIFSITV-ERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNV 290
            |||:..|.: :.::|.:...||. ...|.::|||||||.:.|:..|.||.|...||.||..|||.
Yeast   310 SHAVLQIHIMQTNKLVDLTSQHT-FATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNC 373

  Fly   291 ISALV--DG-KSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNI 352
            |:||.  || :|.|||||:|||||||:.|||||.||||...|||:.|:|.||::||:||:|||.|
Yeast   374 INALCLNDGSRSCHIPYRDSKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEI 438

  Fly   353 QNRMHINEEPKDALLRH---FQEEIARLRKQLEEGDSLEEEPPSSEEEEDTADDELEAPLEIELE 414
            :.::..|::   :|.||   :.:.|...::|:||....||:..|.
Yeast   439 KTKIIRNQQ---SLSRHVGSYLKMITEQKRQIEELREREEKMISL-------------------- 480

  Fly   415 SSTIQAVEKKPKKKREKTDAEKEELAKRK--NEHQKEIEHAKTEQ--ETLRNKLVSLEGKILVGG 475
                       |..:.|.:.||.:||..:  |..|:.....:|.|  :||:: |:..:.:.|
Yeast   481 -----------KLTKYKLNKEKIQLAINECVNRVQQTYAGVETYQVAKTLKS-LILCKRRFL--- 530

  Fly   476 ENLLEKAQTQELLL-----EQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGIT 535
              .:.|.:...|:|     |.:.||::....:...:...|..|..|   :|.::    |.:..::
Yeast   531 --QMVKLEVDNLILLFEREESTAAEMQPVISNCRMISGQLYNKIHE---LEMKF----DETDTLS 586

  Fly   536 KKIHRVMQMLMGVKSELADQQQEHQREKEGIY-ENIRSLSRELALCELVLNSYVPKE-------- 591
            ..||:|..:.:....|:.|..:.:    :.:| |:..:...||...|:::||.:..|
Yeast   587 SVIHQVHSIDLNKLREMEDWDETY----DLVYLESCLNQISELQRNEILVNSSIMTEKLMSDPGL 647

  Fly   592 -----------------YQSMINQYTHWNEDIGEWQLKCVA-----YTGNNM------------- 621
                             .:|:|....|.:|:...:....:|     :|..|:
Yeast   648 NSRFKFLSKWLMNRTPNIESIIQDLVHIDEEFESFARTFIANPDSNFTNTNINIINTTAADLAVP 712

  Fly   622 -----RKHISAHKTSGKEPDF--------------------------LDLSHVYLSYNTDGVSNP 655
                 |::.|..|.....||.                          :|:|....::|..|.|.|
Yeast   713 AETLQRQNFSQKKVKWTSPDLSPSPMIEPQPELEPELHQDQDAIASEVDVSMQDTTFNEQGPSTP 777

  Fly   656 MRSKSARPR 664
            ....:|.||
Yeast   778 SAPTTAVPR 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	148/366 (40%)
		Kinesin	26..352	CDD:278646	145/359 (40%)
		RILP-like	<437..556	CDD:304877	26/127 (20%)
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	148/368 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1240
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860