Protein Alignment Klp64D and Kif3c

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_445938.1
• Gene: Kif3c / 85248
• RGDID: 621538
• Length: 796
• Species: Rattus norvegicus
• Alignment Length: 773
• Identity: 310/773 - (40%)
• Similarity: 443/773 - (57%)
• Gaps: 122/773 - (15%)

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |.::||.|.||:.:.|.:||....:::|.....:|:..|.|...|.|||:.||.|:|..|.|.||
  Rat     9 EALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADL 73

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:|.||::|.||:|:|||:.|||||||||||||.|....|:.:|:|||||.|||.||::: :||
  Rat    74 YDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRS-QNQ 137

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            ::|||.||:|||.||:||||.|:.||.||:||.|:.||::||||.:|..|..::|::|.|||:.|
  Rat   138 QYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQAR 202

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSK----------TQ 268
            |||:|.||:.||||||||.||||.||.|.....|:|:|||.||||||||||:|          ||
  Rat   203 AVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTPGGPATQ 267

  Fly   269 ----------------ASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSL 317
                            :||:|.|||:|||||||.|||||:||...:|||||||:|||||||||||
  Rat   268 STAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSL 332

  Fly   318 GGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLE 382
            |||:||:|.||:.||..:|.|::||||:|:|||||:|:..:||:|||.|||.||||||||:.|||
  Rat   333 GGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLE 397

  Fly   383 EGDSLEEEP-------------PS------------SEEEEDTADDE------LEAPLEIELESS 416
            :...|.:.|             |:            :|||:|..::.      |||.||..:|:
  Rat   398 KKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAALEKNMEN- 461

  Fly   417 TIQAVEKKPKKKREKTDAE------KEELAKRKNEHQKEIEHAKTEQ---ETLRNKLVSLEGKIL 472
              ...|:|.:.:.||...:      .||..|...|.:|.:|..|.||   |.|..|..::|.|:|
  Rat   462 --YLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYKAMESKLL 524

  Fly   473 VGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKK 537
            :||.|:::....|:.:||....|:.:.::.|..::|.:..:..|.:::...||:||......|||
  Rat   525 IGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEVKTKK 589

  Fly   538 IHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHW 602
            :.::...|..||:|:.||.:|:.|.::.:.|.....:|||.|..|::.:::|.|.::.|......
  Rat   590 LKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFL 654

  Fly   603 NEDIGEWQLKCVAYTGNN---MRKH----------ISAH----KTSGKEPDF---------LDLS 641
            :.:..:|:.:.:...|.|   |:|.          ||.:    ...|..|.:         ||:|
  Rat   655 DCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVS 719

  Fly   642 H---VYLSYNTDGVSNP--------MRSKS--ARPRTSGV-------------PRPTT 673
            .   ..:.::.|...:|        ||..|  .||.||.|             |.|:|
  Rat   720 PPAIFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPPST 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	197/358 (55%)
		Smc	<433..>578	CDD:440809	43/153 (28%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	197/358 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..292		10/40 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..421		3/23 (13%)
		Smc	<452..>637	CDD:440809	55/187 (29%)
		Globular. /evidence=ECO:0000255	633..793		29/145 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..796		7/24 (29%)