DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Kif3c

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_445938.1	Gene:	Kif3c / 85248	RGDID:	621538	Length:	796	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	310/773 - (40%)
Similarity:	443/773 - (57%)	Gaps:	122/773 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |.::||.|.||:.:.|.:||....:::|.....:|:..|.|...|.|||:.||.|:|..|.|.||
  Rat     9 EALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADL 73

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:|.||::|.||:|:|||:.|||||||||||||.|....|:.:|:|||||.|||.||::: :||
  Rat    74 YDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRS-QNQ 137

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            ::|||.||:|||.||:||||.|:.||.||:||.|:.||::||||.:|..|..::|::|.|||:.|
  Rat   138 QYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQAR 202

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSK----------TQ 268
            |||:|.||:.||||||||.||||.||.|.....|:|:|||.||||||||||:|          ||
  Rat   203 AVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTPGGPATQ 267

  Fly   269 ----------------ASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSL 317
                            :||:|.|||:|||||||.|||||:||...:|||||||:|||||||||||
  Rat   268 STAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSL 332

  Fly   318 GGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLE 382
            |||:||:|.||:.||..:|.|::||||:|:|||||:|:..:||:|||.|||.||||||||:.|||
  Rat   333 GGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLE 397

  Fly   383 EGDSLEEEP-------------PS------------SEEEEDTADDE------LEAPLEIELESS 416
            :...|.:.|             |:            :|||:|..::.      |||.||..:|:
  Rat   398 KKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAALEKNMEN- 461

  Fly   417 TIQAVEKKPKKKREKTDAE------KEELAKRKNEHQKEIEHAKTEQ---ETLRNKLVSLEGKIL 472
              ...|:|.:.:.||...:      .||..|...|.:|.:|..|.||   |.|..|..::|.|:|
  Rat   462 --YLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYKAMESKLL 524

  Fly   473 VGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKK 537
            :||.|:::....|:.:||....|:.:.::.|..::|.:..:..|.:::...||:||......|||
  Rat   525 IGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEVKTKK 589

  Fly   538 IHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHW 602
            :.::...|..||:|:.||.:|:.|.::.:.|.....:|||.|..|::.:::|.|.::.|......
  Rat   590 LKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFL 654

  Fly   603 NEDIGEWQLKCVAYTGNN---MRKH----------ISAH----KTSGKEPDF---------LDLS 641
            :.:..:|:.:.:...|.|   |:|.          ||.:    ...|..|.:         ||:|
  Rat   655 DCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVS 719

  Fly   642 H---VYLSYNTDGVSNP--------MRSKS--ARPRTSGV-------------PRPTT 673
            .   ..:.::.|...:|        ||..|  .||.||.|             |.|:|
  Rat   720 PPAIFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPPST 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	197/358 (55%)
		Kinesin	26..352	CDD:278646	194/351 (55%)
		RILP-like	<437..556	CDD:304877	37/121 (31%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	197/358 (55%)
		Kinesin	16..367	CDD:278646	194/351 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..292		10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421		3/23 (13%)
		GBP_C	<463..571	CDD:303769	29/107 (27%)
		coiled coil	540..551	CDD:293879	3/10 (30%)
		coiled coil	560..571	CDD:293879	2/10 (20%)
		Globular. /evidence=ECO:0000255	633..793		29/145 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..796		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720