DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and Kif3a

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_006246409.1	Gene:	Kif3a / 84392	RGDID:	621536	Length:	726	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	406/707 - (57%)
Similarity:	503/707 - (71%)	Gaps:	51/707 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQ 80
            :..:||:||||.||:::.|.|.....|:|||::...|||.|.: ::||||||:.||.||...|.|
  Rat    10 ESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTD-SSNEPPKTFTFDTVFGPESKQ 73

  Fly    81 MDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAK 145
            :|:|..|||||:|.|||||||||.||||||||||:||.|....|..:|:|||:|||||||||||:
  Rat    74 LDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAE 138

  Fly   146 ENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGN 210
            .:.:|||||||:||||||||||||||..:.||||||||:||::||||.|||:||||::.||.||:
  Rat   139 GDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGH 203

  Fly   211 KNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLK 275
            |||:||||.||:.||||||||:||:|.||.|.....|||||||.||||||||||:||.|:|||||
  Rat   204 KNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLK 268

  Fly   276 EATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETI 340
            ||||||||||.|||||||||||||||:|||||||||||||||||||||:|||.|.|||.||.|||
  Rat   269 EATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETI 333

  Fly   341 STLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEEDTADDEL 405
            ||||||:|||||:|:..|||:|||||||.||:||..|:|:||||:.:.....|..||:|..:.||
  Rat   334 STLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDNEEGEL 398

  Fly   406 --------------------------EAPLEIELESSTIQAVEKK--PKKKRE------------ 430
                                      |.||:   |....||.:||  |.|..|
  Rat   399 GEDGEKRKKRRGSSSSSSSDSTCSVIEKPLD---EFLPHQAGKKKVSPDKMMEMQAKIDEERKAL 460

  Fly   431 --KTDAEKEELAKRKNE---HQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLE 490
              |.|.|:||..|.:.|   .:|::..|:.|.::|..||.:||.|::|||.:||.||:.||.|||
  Rat   461 ETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLE 525

  Fly   491 QSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQ 555
            :|..|||:..|..|.|::.|::|..||:||||:|::||:.:.|.|||:.:|..|||..|||:||.
  Rat   526 ESNMELEERRKRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL 590

  Fly   556 QQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNN 620
            |||||||.||:.||||.|||||.|..|::::::|::||.||..|.||||||||||||||||||||
  Rat   591 QQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNN 655

  Fly   621 MRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPMRSKSARPRTS-GVPRPTTARR 676
            |||.........::|..:|||||||:|..:.:...: .|..||||| |..||.|.||
  Rat   656 MRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSL-MKLERPRTSKGKARPKTGRR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	237/332 (71%)
		Kinesin	26..352	CDD:278646	232/325 (71%)
		RILP-like	<437..556	CDD:304877	56/121 (46%)
Kif3a	XP_006246409.1	KISc_KIF3	13..345	CDD:276822	237/332 (71%)
		Kinesin	20..345	CDD:278646	232/325 (71%)
		CENP-F_leu_zip	434..574	CDD:287450	57/139 (41%)
		GBP_C	<446..611	CDD:303769	75/164 (46%)
		coiled coil	597..608	CDD:293879	7/10 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353652
Domainoid	1	1.000	458	1.000	Domainoid score	I467
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38266
Inparanoid	1	1.050	753	1.000	Inparanoid score	I541
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0001102
OrthoInspector	1	1.000	-	-		oto96988
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4842
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800