Protein Alignment Klp64D and KIF18A

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_112494.3
• Gene: KIF18A / 81930
• HGNCID: 29441
• Length: 898
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 216/687 - (31%)
• Similarity: 328/687 - (47%)
• Gaps: 143/687 - (20%)

  Fly    15 DDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKP----------NATANE------ 63
            :|...:::||||.||.:..|.:||....:.|  :::.|.|..|          ..|.|:
Human     6 EDLCHHMKVVVRVRPENTKEKAAGFHKVVHV--VDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQ 68

  Fly    64 -PPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTK 127
             ....:.||.|||..|.|.:::..|.:||:...|.|||.|:||||.||.|||:||.|:.|.|
Human    69 NKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEP--- 130

  Fly   128 GIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLS 192
            |::.....|::..:.:.||.:.....|||:|:|||::||||..  ...|.|:|....||.|   .
Human   131 GVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVN--SGPLAVREDTQKGVVV---H 190

  Fly   193 GYVVHNADDLENIMRL---GNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQ 254
            |..:|.....|.|:.|   |||||....|.||..||||||:|.|.:.:.:......|:||:.|:.
Human   191 GLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMS 255

  Fly   255 LVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDG--KSTHIPYRNSKLTRLLQDSL 317
            |:|||||||.|.:.|.|.|..|.|.||.||..|||||:||.|.  |:.|||||||||||||:|||
Human   256 LIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSL 320

  Fly   318 GGNSKTVMCATISPADSNYMETISTLRYASRAKNIQ-----NRMHINEEPKDALLRHFQEEIARL 377
            |||.:|:|.|.:||:...|.:|.:||:||:|||:|:     |.:::|        .|..:.:...
Human   321 GGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVN--------NHITQYVKIC 377

  Fly   378 RKQLEEGDSLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEELAKR 442
            .:|..|...|:|:..:.||::...::..:|.|.|
Human   378 NEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMI------------------------------- 411

  Fly   443 KNEHQKEIEHAKTEQETLRNKLVSLEGKILVGGENLL----EKAQTQELLLEQSIAELEQHEKSE 503
            .|..:||||..   ||.|                |.|    |:.:.:.|.||..:.|.|
Human   412 SNPQEKEIERF---QEIL----------------NCLFQNREEIRQEYLKLEMLLKENE------ 451

  Fly   504 EALKQTLQQKATERIDI---EERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEG 565
              ||...||:..::|::   |::.    :.:||  |:.|| :.||...:|.|..:::|..::.:.
Human   452 --LKSFYQQQCHKQIEMMCSEDKV----EKATG--KRDHR-LAMLKTRRSYLEKRREEELKQFDE 507

  Fly   566 IYENIRSLSRELALCELVLNSYVPKEYQSMIN-QYTH-WNEDIGE-----WQLKCVAYTGN---- 619
            ....:..:.:|:.|  |..|.::|||.:..:: .:.| .|:|:..     ..|.|:....:
Human   508 NTNWLHRVEKEMGL--LSQNGHIPKELKKDLHCHHLHLQNKDLKAQIRHMMDLACLQEQQHRQTE 570

  Fly   620 --------NMRKHISAHKTSGK-----EPDFLDLSHV 643
                    .:||.....|.:|.     |.||.::.|:
Human   571 AVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHL 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	150/354 (42%)
		Smc	<433..>578	CDD:440809	33/151 (22%)
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	150/353 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..690
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..871