DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Kif26a

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_006516225.1	Gene:	Kif26a / 668303	MGIID:	2447072	Length:	1913	Species:	Mus musculus

Alignment Length:	516	Identity:	138/516 - (26%)
Similarity:	236/516 - (45%)	Gaps:	101/516 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKP-----------NATANEPPKTYYFDNVF 74
            |:|::|..|....:.||.:.|.:.||...:.:|:..|           :|.....||.:.||.:|
Mouse   397 VKVMLRIWPAQGVQRSAESTSFLKVDSRKKQVTLYDPAAGPPGCAGLRHAPTAPVPKMFAFDAIF 461

  Fly    75 DGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFG 139
            ...|.|.::...|...::..|:.|.:|.|.::|....||:|||.|...|||:.||:|.|.:.:|.
Mouse   462 PQDSEQAEVCSGTVADVLQSVVSGADGCIFSFGHMSLGKSYTMIGKDSSPQSLGIVPCAISWLFR 526

  Fly   140 HIAKAKE--NQKFLVRVSYMEI--YNEEVRDLLGKDVGKSLEVKERPDIGVFVKD--LSGYVVHN 198
            .|.:.||  ..:|.:|||.:|:  :::.:||||.:....||:..:.|  ||::::  :.|..:.|
Mouse   527 LIDERKERLGTRFSIRVSAVEVCGHDQSLRDLLAEVASGSLQDTQSP--GVYLREDPVCGTQLQN 589

  Fly   199 ADDLENIMRLGNKNRAVGATK------------------MNQESSR-SHAIFSITVER---SELG 241
            .::|          ||..|.|                  ..:|:.| ||.:|::.|.:   .:.|
Mouse   590 QNEL----------RAPTAEKAAFYLDAALAARSTSRAGCGEEARRSSHMLFTLHVYQYRVEKCG 644

  Fly   242 EGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT--KINLSLSVLGNVISALVDGKSTHIPY 304
            :|.:...| .:|.|:||...:      |:..|..||:  .:.||||.||:||.|||:| :.|:||
Mouse   645 QGGMSGGR-SRLHLIDLGSCD------AAVGRGGEASGGPLCLSLSALGSVILALVNG-AKHVPY 701

  Fly   305 RNSKLTRLLQDSLG-GNSKTVMCATISPADSNYMETISTLRYASRAKNIQNR--MHINEEP---- 362
            |:.:||.||::||. .|.:|.|.|.||.:.:::.||:||::.|:|...::.:  .|.:...
Mouse   702 RDHRLTMLLRESLATTNCRTTMIAHISDSPAHHAETLSTVQLAARIHRLRRKKGKHASSSSGGES 766

  Fly   363 --------KDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEEDTADDEL-EAPLEIELESSTI 418
                    :...||.|......|... .....|..:|..|...|.:.|..: ..|..:.|..
Mouse   767 SCEEGRARRPPHLRPFHPRAVVLDPD-RSAPGLSGDPDYSSSSEQSCDTVIYVGPGGMALSD--- 827

  Fly   419 QAVEKKPKKKREKTDAEK--------EELAKRK-NEHQKEIEHAKTEQ-ETLRNKLVSLEG 469
                      ||.||.|.        ..|::|: :|..::.:|.:... ..|:.:|..::|
Mouse   828 ----------RELTDNEGPPDFVPIIPALSRRRPSEGPRDADHFRCSTFAELQERLECIDG 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	114/372 (31%)
		Kinesin	26..352	CDD:278646	112/367 (31%)
		RILP-like	<437..556	CDD:304877	7/35 (20%)
Kif26a	XP_006516225.1	KISc	396..748	CDD:276812	114/370 (31%)
		PRK07764	<869..1301	CDD:236090	3/10 (30%)
		PHA03247	<1154..1647	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900