Protein Alignment Klp64D and KIF9

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001400905.1
• Gene: KIF9 / 64147
• HGNCID: 16666
• Length: 823
• Species: Homo sapiens
• Alignment Length: 692
• Identity: 201/692 - (29%)
• Similarity: 314/692 - (45%)
• Gaps: 140/692 - (20%)

  Fly    19 ENVRVVVRTRPMD--KNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQM 81
            :.|...||.:|.|  .:|:........|:| |:....:.:......:...::..|.|....|..:
Human    38 KKVHAFVRVKPTDDFAHEMIRYGDDKRSID-IHLKKDIRRGVVNNQQTDWSFKLDGVLHDASQDL 101

  Fly    82 DLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKE 146
             :|...|:.:|.:.|:||||||:.|||||.||||||.|..::.:.:||:|.|...:| .:.:.:.
Human   102 -VYETVAKDVVSQALDGYNGTIMCYGQTGAGKTYTMMGATENYKHRGILPRALQQVF-RMIEERP 164

  Fly   147 NQKFLVRVSYMEIYNEEVRDLLG--KDVGKS---LEVKERPDIGVFVKDLSGYVVHNADDLENIM 206
            .....|||||:|||||.:.|||.  ..||.|   :.:.|.|. |||:|.||.::....:|..:::
Human   165 THAITVRVSYLEIYNESLFDLLSTLPYVGPSVTPMTIVENPQ-GVFIKGLSVHLTSQEEDAFSLL 228

  Fly   207 RLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASG 271
            ..|..||.:.:..||:.|||||.||:|.:|.......:.::: ..|:.|||||||||..|:.:.|
Human   229 FEGETNRIIASHTMNKNSSRSHCIFTIYLEAHSRTLSEEKYI-TSKINLVDLAGSERLGKSGSEG 292

  Fly   272 QRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNY 336
            |.|||||.||.|||.|...|.||.|.|..|||:|..|||..|:||||||...|:...|....:..
Human   293 QVLKEATYINKSLSFLEQAIIALGDQKRDHIPFRQCKLTHALKDSLGGNCNMVLVTNIYGEAAQL 357

  Fly   337 METISTLRYASRAKNIQNRMHINEE-PKDALLRHFQEEIARLRKQLEEGDSLEEE-----PPSSE 395
            .||:|:||:|||.|.:.....|||: ..:.::::.::|:|.|:::|...|||...     .|..|
Human   358 EETLSSLRFASRMKLVTTEPAINEKYDAERMVKNLEKELALLKQELAIHDSLTNRTFVTYDPMDE 422

  Fly   396 EE------------EDTADD-------------------------ELEAPLEIEL------ESST 417
            .:            |.|.|:                         |:|:.|..:.      :.:.
Human   423 IQIAEINSQVRRYLEGTLDEIDIISLRQIKEVFNQFRVVLSQQEQEVESTLRRKYTLIDRNDFAA 487

  Fly   418 IQAVEK----------------------------KPKKKREKTDAEKEELAK--RKN-----EHQ 447
            |.|::|                            ||.||.:.....||.|:.  ||.     .:.
Human   488 ISAIQKAGLVDVDGHLVGEPEGQNFGLGVAPFSTKPGKKAKSKKTFKEPLSSLARKEGASSPVNG 552

  Fly   448 KEIEHAKTEQETLRNKLV--SLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEE------ 504
            |::::..|.    :.:||  |.:|.:    :::|.:.:.     ..||..|......||
Human   553 KDLDYVSTS----KTQLVPSSKDGDV----KDMLSRDRE-----TSSIEPLPSDSPKEELRPIRP 604

  Fly   505 --------ALKQTLQQKATE--RIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSEL-----AD 554
                    |.::...::.:|  || .:|..|.|.:.    .|:.....|.:..:|.|:     |.
Human   605 DTPPSKPVAFEEFKNEQGSEINRI-FKENKSILNER----RKRASETTQHINAIKREIDVTKEAL 664

  Fly   555 QQQEHQREKEGIYEN--IRSLSRELALCELVLNSYVPKEYQS 594
            ..|:..|||:|.|||  :..:..|..|..|.|.. :.|:|:|
Human   665 NFQKSLREKQGKYENKGLMIIDEEEFLLILKLKD-LKKQYRS 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	132/339 (39%)
		Smc	<433..>578	CDD:440809	38/176 (22%)
KIF9	NP_001400905.1	KISc_KIF9_like	39..371	CDD:276826	131/336 (39%)