DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and kif15

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_002666969.1	Gene:	kif15 / 573988	ZFINID:	ZDB-GENE-050622-16	Length:	1376	Species:	Danio rerio

Alignment Length:	634	Identity:	213/634 - (33%)
Similarity:	335/634 - (52%)	Gaps:	81/634 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EANAGTTAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVD-KINRAITVMKPNAT---ANEPP 65
            :..|...|..:.:.:.::|.||.||:.:.       :.:|.| ..:..:||..|...   ....|
Zfish     4 KGKATAEANTNSDGDAIKVFVRVRPLTQG-------TGLSTDGDHSLCLTVSSPQTVRLHCKPEP 61

  Fly    66 KTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPD----SPQT 126
            :|:.:|:|.|..::|.:::...|:.||:..:.||||||.||||||:|||:||.|..:    |.:.
Zfish    62 RTFTYDHVADMNTSQEEVFSSVAKNIVESCMNGYNGTIFAYGQTGSGKTFTMLGPSELDNFSDEL 126

  Fly   127 KGIIPNAFAHIFGHIAKAKE----NQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVF 187
            :|:||.:|.::|..|.:..|    .:.||.:.|::|||||::.||| ..|..||.::|....|||
Zfish   127 RGVIPRSFEYLFFLINREVERSGGTKSFLCKCSFIEIYNEQIYDLL-DSVSTSLFLREDIKRGVF 190

  Fly   188 VKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGK 252
            |:........:|.:...::.:|.:||.|.:|.||:|||||||:|::|:|..|.|: :|.::|..:
Zfish   191 VEGSVEKYAASAAEAYQVLSMGWRNRRVASTSMNRESSRSHAVFTMTLESKETGQ-EVVNIRTSQ 254

  Fly   253 LQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD---GKSTHIPYRNSKLTRLLQ 314
            |.||||||||||..|...|.|||||:.||.||..||.||.||:|   ||:.||.||:||||.||:
Zfish   255 LNLVDLAGSERQRDTHTEGSRLKEASSINRSLMCLGQVIMALMDVSNGKNRHICYRDSKLTFLLR 319

  Fly   315 DSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRK 379
            ||||||:||.:.|.:.|....:.||:|||::|.|||.|:|:..:||:.: ..:|..|.|:.:|::
Zfish   320 DSLGGNAKTYIIANVHPGSKCFGETLSTLQFAQRAKLIKNKAMVNEDTQ-GNVRQLQAEVRKLKE 383

  Fly   380 Q----LEEGDSLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAV--------EKKPKKKR--- 429
            |    |.:|..:|..|      .|...|:.|.  |:..::..|||:        |||..:::
Zfish   384 QLANALSQGRIVELAP------TDATSDQSEP--EVSYKTQFIQAMNFWKKIHEEKKALQQKVSQ 440

  Fly   430 -EKTDAEKEE-------LAKRKNEH----QKEIE--HAKTEQETLRNKLVSLEGKIL-------- 472
             |...|:||:       :.|.:::|    :||::  ....|.|.| ||.:..|.::|
Zfish   441 LEAAWAQKEKFIQSNRMILKFRDDHIAQLKKELQTGQRSVEPEEL-NKQLQDEIRLLRDQVEHNP 504

  Fly   473 ----VGGENLLEKAQTQELLLEQSI-AELEQHEKSEEALKQT-LQ----QKATERIDIEERYSTL 527
                ...||...:.:.:.|....|: :.:|...:|..||::| ||    ||..:.......|||.
Zfish   505 RMMRYAAENCSLREEIRALRALDSVKSAMESKAQSLTALEKTFLQLLEAQKTEDSNGAPPTYSTP 569

  Fly   528 QDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRE 576
            ....|..:..:.|:...|:..:|||....|..:..||...:.:..|..|
Zfish   570 VTMETLSSVSMERMKVQLLQKQSELTATIQAFEEFKEVTKKQVAELESE 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	146/347 (42%)
		Kinesin	26..352	CDD:278646	144/340 (42%)
		RILP-like	<437..556	CDD:304877	34/149 (23%)
kif15	XP_002666969.1	KISc_KLP2_like	18..367	CDD:276824	150/357 (42%)
		KISc	19..364	CDD:214526	148/353 (42%)
		SbcC	371..1007	CDD:223496	61/257 (24%)
		Kinesin-relat_1	462..547	CDD:289481	18/85 (21%)
		Ax_dynein_light	<602..658	CDD:287215	4/17 (24%)
		GBP_C	<707..805	CDD:303769
		Mplasa_alph_rch	709..1360	CDD:275316
		coiled coil	776..788	CDD:293879
		coiled coil	794..805	CDD:293879
		HMMR_C	1262..>1372	CDD:292530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810