Protein Alignment Klp64D and KIF15

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_016862373.1
• Gene: KIF15 / 56992
• HGNCID: 17273
• Length: 1411
• Species: Homo sapiens
• Alignment Length: 707
• Identity: 228/707 - (32%)
• Similarity: 354/707 - (50%)
• Gaps: 122/707 - (17%)

  Fly     9 GTTAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNAT---ANEPPKTYYF 70
            |.:.|..:|.:.::|.||.||..:...||..       :.|..::|:...:.   :|..|||:.|
Human    15 GQSNQPSNEGDAIKVFVRIRPPAERSGSADG-------EQNLCLSVLSSTSLRLHSNPEPKTFTF 72

  Fly    71 DNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSP----QTKGIIP 131
            |:|.|..:.|..::...|:.||:..:.||||||.||||||:|||:||.|..:|.    ..:|:||
Human    73 DHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIP 137

  Fly   132 NAFAHIFGHIAKAKE----NQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLS 192
            .:|.::|..|.:.||    .:.||.:.|::|||||::.||| ......|.::|....||||....
Human   138 RSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL-DSASAGLYLREHIKKGVFVVGAV 201

  Fly   193 GYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVD 257
            ..||.:|.:...::..|.:||.|.:|.||:|||||||:|:||:|..| ...::.::|...|.|||
Human   202 EQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESME-KSNEIVNIRTSLLNLVD 265

  Fly   258 LAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD---GKSTHIPYRNSKLTRLLQDSLGG 319
            |||||||..|.|.|.|||||..||.|||.||.||:||||   ||..|:.||:||||.||:|||||
Human   266 LAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGG 330

  Fly   320 NSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEG 384
            |:||.:.|.:.|....:.||:|||.:|.|||.|:|:..:||:.: ..:...|.|:.||::||.|.
Human   331 NAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQ-GNVSQLQAEVKRLKEQLAEL 394

  Fly   385 DSLEEEPPS------------------------SEEEED------TADDELEAPLE--------- 410
            .|.:..|.|                        ||:|:.      |..::|....|
Human   395 ASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMI 459

  Fly   411 IELESSTIQAVEKKPKKKREKTDAEKEE--LAKRKNEHQ---KEIE-HAKTEQETLRNKLVSLEG 469
            ::.....|..:||..|:.|.....|:::  |::.:||.|   ::|| |.:..:..:.|..:..|.
Human   460 VKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREEN 524

  Fly   470 KILVGGENLLEKAQTQELLLEQSIAELEQ-------HEKSEEALKQTLQQKATERIDIEERYSTL 527
            :.|    .|||..:..:.:..|:||:||:       .|||::.               ::.:|..
Human   525 RRL----RLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKN---------------QQGFSPK 570

  Fly   528 QDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEY 592
            ......:.....::...|:.:::||.:.:||        ||..:.|:|:.   :|.|.|    |.
Human   571 AQKEPCLFANTEKLKAQLLQIQTELNNSKQE--------YEEFKELTRKR---QLELES----EL 620

  Fly   593 QSMINQYTHWN-EDIGEWQLKCVAYTGNNMRKHISAHKTSGKEPDFLDLSHVYLSYN 648
            ||:  |..:.| |::.|....|       .|:.:|  :.:....:.|.|.:|...||
Human   621 QSL--QKANLNLENLLEATKAC-------KRQEVS--QLNKIHAETLKLKNVMWIYN 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	150/346 (43%)
		Smc	<433..>578	CDD:440809	32/157 (20%)
KIF15	XP_016862373.1	KISc_KLP2_like	25..373	CDD:276824	154/356 (43%)
		SMC_N	<371..643	CDD:481474	65/315 (21%)
		SMC_prok_B	<579..1362	CDD:274008	27/114 (24%)