DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and kif17

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001373250.1	Gene:	kif17 / 557863	ZFINID:	ZDB-GENE-080724-12	Length:	823	Species:	Danio rerio

Alignment Length:	798	Identity:	292/798 - (36%)
Similarity:	426/798 - (53%)	Gaps:	151/798 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |:|:||||.||::..|.:......:|||..:....:.||..| .||||.:.||..:....:..::
Zfish     4 ESVKVVVRCRPLNNREKAMNCKIVVSVDSTHCQCFIKKPGDT-EEPPKQFTFDGTYYINHSTEEV 67

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:.|.|:|:.|.|||||||.||||||:||::||.|.||.|..:||||.||.|||..| :..||.
Zfish    68 YNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGVPDPPSQRGIIPRAFEHIFETI-QCAENT 131

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            |||||.||:|||.||:|||||||:.:.:|:||.|:.||:|:||:...||:..:.|.:|.||.:||
Zfish   132 KFLVRASYLEIYKEEIRDLLGKDIKQKMELKEHPERGVYVRDLTMQTVHSVGECERVMDLGWRNR 196

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT 278
            :||.|.||::|||||:||:|.:|...:.....:|:|.|||.|||||||||||||.|:|.||:|||
Zfish   197 SVGYTLMNKDSSRSHSIFTIHLEICSIDTAGDEHLRAGKLNLVDLAGSERQSKTGATGDRLQEAT 261

  Fly   279 KINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTL 343
            |||||||.|||||||||||:|.:||||:||||||||||||||::|:|.|.:||||:||.|:||||
Zfish   262 KINLSLSALGNVISALVDGRSKYIPYRDSKLTRLLQDSLGGNTRTLMVACLSPADNNYEESISTL 326

  Fly   344 RYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLE------------------EGDSLEEE 390
            |||:|||:||||..|||:|||||||.:||||.:||..:.                  |..::...
Zfish   327 RYANRAKSIQNRPRINEDPKDALLREYQEEIKKLRALISGQLGSGNLSSFLAGQKSGEASAVVSR 391

  Fly   391 PPS----SEEEEDTADDE-------LEAPLEIELES----------------STIQAVEKKPKKK 428
            |.|    ||.|:|...:|       |:|..:.|.||                :.:.::|:....:
Zfish   392 PQSNTSESEAEKDKIKEEYEKKLARLQAEYDAEQESKVKLQEDIAALRTSYETRLSSLERSRGSR 456

  Fly   429 REKT-----DAEKEE--LAKRKNEHQKEIEHAKTEQ-----------------ETLRNKLVSLEG 469
            ...|     ...|||  .|...::.|.:|:|:::|:                 :.|.:.:|.:.|
Zfish   457 THTTGGVHLQQHKEEPITASAASQEQAKIDHSESEERPSSVDATVKGAASGESQILDSVVVDIPG 521

  Fly   470 KI---------------LVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERID 519
            ::               .||||.:..:...|.....:::|: ::.::..|||.|:.:...:..::
Zfish   522 QLDQKLALERLQQLEQEFVGGEQVRNEELKQRHKQRKTLAD-QRKKQLIEALNQSSEDGDSVLLN 585

  Fly   520 IEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVL 584
            :   |.::|:.....::.:....:.|...|.|:.|.|.|.:.|:......||.|.||..|.:.:|
Zfish   586 V---YDSIQEEVHAKSRHLENTQKKLKAAKLEIRDLQAEFEMERNDYLATIRRLEREGQLLQGIL 647

  Fly   585 N---SYVPKE--YQSM--INQYTHWNEDIGEWQ----------LKCVAYTGNNMRKHISAHKTSG 632
            .   |.|.::  |.::  :.:...|:|:.|.|:          |..|..:|......:||.:.|.
Zfish   648 ERMVSLVRRDCNYSNLDRLRKEAVWDEEGGTWRLPDVLVQKTTLPAVPPSGVIAPGRLSARRNSA 712

  Fly   633 KE--------------PDFL---DLSHVYLSY----------NTDGVSNPMR------SKSARPR 664
            .:              .:.|   |..|:..:|          .||.|.|.|.      :.||...
Zfish   713 SDLADPFVQEEEQDRYKEMLNRSDSEHIATNYFRPKRSSQLLATDSVKNSMNFSSSVSNGSAHQS 777

  Fly   665 TSG-----------VPRP 671
            :||           :|||
Zfish   778 SSGSGLSALTVESILPRP 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	191/332 (58%)
		Kinesin	26..352	CDD:278646	186/325 (57%)
		RILP-like	<437..556	CDD:304877	26/152 (17%)
kif17	NP_001373250.1	Motor_domain	4..335	CDD:419868	191/332 (58%)
kif17	NP_001373250.1	Smc	395..>650	CDD:224117	49/258 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820