Protein Alignment Klp64D and KIF16B

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_005260807.1
• Gene: KIF16B / 55614
• HGNCID: 15869
• Length: 1883
• Species: Homo sapiens
• Alignment Length: 753
• Identity: 235/753 - (31%)
• Similarity: 339/753 - (45%)
• Gaps: 198/753 - (26%)

  Fly    20 NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMK-PNA----TANEPPKTYYFDNVFDGGSN 79
            :|:|.||.|||::.|....|...|.::|....||.:| |..    :..|..||:.:|..|.....
Human     3 SVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSFYSADT 67

  Fly    80 QMDLYVD-------TARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNP-DSPQTKGIIPNAFAH 136
            :...||.       ....:|....||||..:.||||||:||:|||.||. ||    |:||.....
Human    68 KSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDS----GLIPRICEG 128

  Fly   137 IFGHIAKAK--ENQKFLVRVSYMEIYNEEVRDLLGKDVGK--SLEVKERPDIGVFVKDLSGYVVH 197
            :|..|.:..  :...|...|||:|||||.|||||.:...|  :|.|:|.|..|.:|:|||.::|.
Human   129 LFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQ 193

  Fly   198 NADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSE 262
            |..|:|.:|..||.||...||.||..||||||||:|...:::. :.::....:.|:.||||||||
Human   194 NYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKF-DSEMPCETVSKIHLVDLAGSE 257

  Fly   263 RQSKTQASGQRLKEATKINLSLSVLGNVISALVD-----------GKSTHIPYRNSKLTRLLQDS 316
            |...|.|:|.||||...||.||..||||||||.|           .|...:|||:|.||.||:||
Human   258 RADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDS 322

  Fly   317 LGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQL 381
            |||||||:|.|||||||.||.||:||||||:|||||.|:..|||:....|:|..:.|||||:..|
Human   323 LGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLL 387

  Fly   382 EEGD--SLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTD--AEKEELAKR 442
            .:|:  :|.:.|.:...||           :::...:.:|.:.|:...|..:|.  .:::.||.|
Human   388 AQGNQIALLDSPTALSMEE-----------KLQQNEARVQELTKEWTNKWNETQNILKEQTLALR 441

  Fly   443 KN---------------------------EHQKE------IEHAKTEQETLRN------------ 462
            |.                           .|.||      .:.|.|||:.:.:
Human   442 KEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHCIFE 506

  Fly   463 ------KLVSLEGK--------------------ILVGGENL----------------------- 478
                  .|:.|.|.                    ||:|..|:
Human   507 NIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSS 571

  Fly   479 -------------------------------------LEKAQTQELLLEQS----IAELEQHEKS 502
                                                 .|:.|.:||...:|    |.|:|:.:||
Human   572 FSLSMTDLSKSRENLSAVMLYNPGLFPIKGPICLRLEFERQQREELEKLESKRKLIEEMEEKQKS 636

  Fly   503 EEALKQTLQQ------KATE--RIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQE- 558
            ::|..:.:||      |.||  ::.|.::..:|:..|..|..|:..::......:.|...:|||
Human   637 DKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLREQQEI 701

  Fly   559 ---HQREKEGIYENIRSLSRELALCELVLNSYVPKEYQ 593
               .:|::|   |....:..||...:.:.|:...:::|
Human   702 ELQKKRQEE---ETFLRVQEELQRLKELNNNEKAEKFQ 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	162/359 (45%)
		Smc	<433..>578	CDD:440809	47/293 (16%)
KIF16B	XP_005260807.1	KISc_KIF1A_KIF1B	2..365	CDD:276816	165/366 (45%)
		Kinesin_assoc	364..476	CDD:465047	26/122 (21%)
		FHA_KIF16B	446..562	CDD:438784	14/115 (12%)
		Smc	<606..>1089	CDD:440809	32/134 (24%)