Protein Alignment Klp64D and KIF27

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_011517150.1
• Gene: KIF27 / 55582
• HGNCID: 18632
• Length: 1427
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 217/739 - (29%)
• Similarity: 343/739 - (46%)
• Gaps: 162/739 - (21%)

  Fly    21 VRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDLYV 85
            |:|.||.||:...|........:.|...::.:.:.:        .:.:.||.||...|.|.::|.
Human     6 VKVAVRIRPLLCKEALHNHQVCVRVIPNSQQVIIGR--------DRVFTFDFVFGKNSTQDEVYN 62

  Fly    86 DTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQT---KGIIPNAFAHIFGHIAKAKEN 147
            ...:|:|..::||||.|:.||||||:|||||:.|...:...   |||||.|...||..|:: ..:
Human    63 TCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHIASVVEGQKGIIPRAIQEIFQSISE-HPS 126

  Fly   148 QKFLVRVSYMEIYNEEVRDLLGKDVG-KSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNK 211
            ..|.|:|||:|:|.|::||||..:.. |.|.::|.......:.......|.:|.::.:::.:||.
Human   127 IDFNVKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECHVESAGEVMSLLEMGNA 191

  Fly   212 NRAVGATKMNQESSRSHAIFSITV-------ERSELGEG-DVQHVRMGKLQLVDLAGSERQSKTQ 268
            .|..|.|:||:.||||||||:|::       |.:|.|.. ..:|: :.|...||||||||.:||.
Human   192 ARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHI-VSKFHFVDLAGSERVTKTG 255

  Fly   269 ASGQRLKEATKINLSLSVLGNVISALVD--GKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISP 331
            .:|:|.||:.:||..|..||||||||.|  .||:|||||::|:||||:|||||::||||...:||
Human   256 NTGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSP 320

  Fly   332 ADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLE-------------- 382
            :.||:.|::::|:||:||:||:|:..:|..|:...:...:.||..||:.|:
Human   321 SSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAGVSQTTQINR 385

  Fly   383 EGD-------SLEEEPPSSEEE------------------EDTA------DDELE---------- 406
            ||.       ||||:....:.|                  :||.      ..:|:
Human   386 EGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEKQQHKLQEWFNMIQEVR 450

  Fly   407 -------------APLEIELESSTIQAVEKKPKKKR------EKTDAEKE-ELAKRKNEHQKEIE 451
                         |.||...:..|:..::::.||.:      |....:|| |:.:.||:.|..::
Human   451 KAVLTSFRGIGGTASLEEGPQHVTVLQLKRELKKCQCVLAADEVVFNQKELEVKELKNQVQMMVQ 515

  Fly   452 HAKTEQETLR-----NKLVSLEGKILVGGENLL-------------EKAQTQELLLEQSIAELEQ 498
            ..|....:|:     |:|..|....|:.....|             ||...|:||::|...||.:
Human   516 ENKGHAVSLKEAQKVNRLQPLAKTTLLSTSMDLPILNISYNWNHTNEKIIEQQLLVDQLSEELTK 580

  Fly   499 HEKS-EEALKQTLQQKATERIDIEERYSTLQDASTG---------ITKKIH---------RVM-- 542
            ...| ..:.|:........||.....|:...|...|         .::|:|         |:.
Human   581 LNLSVTSSAKENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQDSRKVHTSPPMYSLDRIFAG 645

  Fly   543 -----QMLMG-----------VKSELADQQQEHQREKEGIYENIRS-LSRELALCELVLNSYVPK 590
                 |||:|           ..|:.:|.::...:||.|.....|| :.:..::|.||..|....
Human   646 FRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQD 710

  Fly   591 EYQSMINQYTHWNEDIGEWQLKCV 614
            |.|....:    |||:   ::.|:
Human   711 ETQKSDLE----NEDL---KIDCL 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	138/344 (40%)
		Smc	<433..>578	CDD:440809	42/201 (21%)
KIF27	XP_011517150.1	KISc_KIF4	4..342	CDD:276823	139/345 (40%)
		PTZ00121	<658..1227	CDD:173412	17/77 (22%)