DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and kif3a

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001017604.2	Gene:	kif3a / 550267	ZFINID:	ZDB-GENE-050417-71	Length:	701	Species:	Danio rerio

Alignment Length:	695	Identity:	399/695 - (57%)
Similarity:	503/695 - (72%)	Gaps:	28/695 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPQEEANAGTTAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPP 65
            ||..:.:.....::.|   ||:||||.||:::.|...|...:::||:|...|||.|.: .::|||
Zfish     1 MPSNKLDKPEKLEVSD---NVKVVVRCRPLNEKEKIMGHKQSVTVDEIRGTITVNKLD-ISSEPP 61

  Fly    66 KTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGII 130
            ||:.||.||...|.|:|:|..|||||:|.|||||||||.||||||||||:||.|....|:.:|||
Zfish    62 KTFTFDTVFGPDSKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELRGII 126

  Fly   131 PNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYV 195
            ||:|||:|||||||:.:.:|||||||:||||||||||||||..:.||||||||:||::|||||||
Zfish   127 PNSFAHVFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQMQRLEVKERPDVGVYIKDLSGYV 191

  Fly   196 VHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAG 260
            |:||||::.||.||:|||:||||.||:.||||||||:||:|.||.|....||||||||.||||||
Zfish   192 VNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNQHVRMGKLHLVDLAG 256

  Fly   261 SERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVM 325
            ||||.||.|:|||||||||||||||.|||||||||||||||:|||||||||||||||||||||:|
Zfish   257 SERQGKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMM 321

  Fly   326 CATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEE 390
            ||.|.|||.||.|||||||||:|||||:|:..|||:|||||||.||:||..|:|:||||:.:...
Zfish   322 CANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGS 386

  Fly   391 PPSSE---EEEDTAD-----------DELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEELAK 441
            ..|..   :|:|..|           .::.....:|:::.    :|::.|....|.|.|:||..|
Zfish   387 DGSGSDDMDEDDVGDGGERRRKRRGRKKVSPDKMVEMQAK----IEEERKALEAKLDMEEEERNK 447

  Fly   442 RKNE---HQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSE 503
            .:.|   .:|::..|:.|...|..||.:||.:::|||.:||.||:.||.|||:|..|||:..|..
Zfish   448 ARAELEKREKDLLKAQQEHHLLLEKLSALEKRVIVGGVDLLAKAEEQEKLLEESNNELEERRKRA 512

  Fly   504 EALKQTLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYE 568
            |.|::.|::|..||:||||:|::||:.:.|.|||:.:|..|||..|||:||.||||.||.||:.|
Zfish   513 EQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHHREIEGLLE 577

  Fly   569 NIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNNMRKHISAHKTSGK 633
            |||.|||||.|..|::::::|:|||.||..|.|||||||||||||||||||||||.........|
Zfish   578 NIRQLSRELRLQMLIIDNFIPQEYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVSDKKEK 642

  Fly   634 EPDFLDLSHVYLSYNTDGVSNPMRSKSARPRTS--GVPRPTTARR 676
            :|..:|||||||:|..:.:...: .|..|||||  |..||.|.||
Zfish   643 DPFEVDLSHVYLAYTEESMRQSL-MKLERPRTSKNGKSRPKTGRR 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	237/332 (71%)
		Kinesin	26..352	CDD:278646	232/325 (71%)
		RILP-like	<437..556	CDD:304877	55/121 (45%)
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	238/335 (71%)
kif3a	NP_001017604.2	Kinesin	23..348	CDD:278646	232/325 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595800
Domainoid	1	1.000	459	1.000	Domainoid score	I466
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38266
Inparanoid	1	1.050	747	1.000	Inparanoid score	I556
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0001102
OrthoInspector	1	1.000	-	-		oto41503
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	1	1.000	-	-		X4842
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830