DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp64D and KIF1A

DIOPT Version :10

Sequence 1:NP_523934.1 Gene:Klp64D / 38611 FlyBaseID:FBgn0004380 Length:677 Species:Drosophila melanogaster
Sequence 2:XP_047300774.1 Gene:KIF1A / 547 HGNCID:888 Length:1825 Species:Homo sapiens


Alignment Length:769 Identity:224/769 - (29%)
Similarity:326/769 - (42%) Gaps:235/769 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVF--------DG 76
            :|:|.||.||.:..|:|..:...|.:.  ....|::.|. ...|.||::.||..:        ..
Human     5 SVKVAVRVRPFNSREMSRDSKCIIQMS--GSTTTIVNPK-QPKETPKSFSFDYSYWSHTSPEDIN 66

  Fly    77 GSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHI 141
            .::|..:|.|....::....||||..|.||||||.||:|||.|..:..| :||||.....:|..|
Human    67 YASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQ-QGIIPQLCEDLFSRI 130

  Fly   142 -AKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENI 205
             ....:|..:.|.|||||||.|.|||||......:|.|:|.|.:|.:|:|||...|.:.:|::::
Human   131 NDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDL 195

  Fly   206 MRLGNKNRAVGATKMNQESSRSHAIFSI--TVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQ 268
            |..|||.|.|.||.||:.||||||:|:|  |.:|.: .|.::...::.|:.|||||||||...|.
Human   196 MDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHD-AETNITTEKVSKISLVDLAGSERADSTG 259

  Fly   269 ASGQRLKEATKINLSLSVLGNVISALVD-----------GKSTHIPYRNSKLTRLLQDSLGGNSK 322
            |.|.||||...||.||:.||.|||||.:           .|:..||||:|.||.||:::|||||:
Human   260 AKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSR 324

  Fly   323 TVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLR--------- 378
            |.|.|.:||||.||.||:||||||.|||.|:....|||:|.:.|:|..::|:.|||         
Human   325 TAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLG 389

  Fly   379 --------------------KQLEEGDSLEEEP-------------------------------- 391
                                ..|..|.::.|.|                                
Human   390 DITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSSRAASVSSL 454

  Fly   392 -------PSSEEE--------------EDTADDELEAPLEIELESSTIQA---VEKK-------- 424
                   |.|||.              .:|.:::|.....|.:|...:.|   |..:        
Human   455 HERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGV 519

  Fly   425 --PKKKREKTDAEKEEL----------------AKRKNEHQKEI---------EHA--KTEQETL 460
              |||.....:..::.|                .:...|.:::|         ||.  :::....
Human   520 FSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGG 584

  Fly   461 RNKLVSLE----------GK------ILVGGENLL-----------------EKAQT-------- 484
            ...:|:||          ||      ||..|..::                 |:.:|        
Human   585 SEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAE 649

  Fly   485 --------QELL----------LEQSIAELE-QHEKSEEALKQTLQQKATERIDIEERYSTLQDA 530
                    :|||          :||.:.||| |:.:..|.....|:|   :|:|.|.:...||  
Human   650 PVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQ---QRLDYESKLEALQ-- 709

  Fly   531 STGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVL 584
                       .||......|:.::::|.:.|       ::...||   |||.|
Human   710 -----------KQMDSRYYPEVNEEEEEPEDE-------VQWTERE---CELAL 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp64DNP_523934.1 KISc_KIF3 19..352 CDD:276822 153/353 (43%)
Smc <433..>578 CDD:440809 39/231 (17%)
KIF1AXP_047300774.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 154/360 (43%)
Kinesin_assoc 358..549 CDD:465047 28/190 (15%)
FHA_KIF1A 525..639 CDD:438778 14/113 (12%)
ERM_helical 658..>711 CDD:466641 17/68 (25%)
KIF1B 839..886 CDD:463574
DUF3694 1275..1431 CDD:463599
PH_KIFIA_KIFIB 1706..1808 CDD:269939
Blue background indicates that the domain is not in the aligned region.

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