Protein Alignment Klp64D and Kif17

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_038967234.1
• Gene: Kif17 / 500571
• RGDID: 1562511
• Length: 1075
• Species: Rattus norvegicus
• Alignment Length: 625
• Identity: 268/625 - (42%)
• Similarity: 358/625 - (57%)
• Gaps: 74/625 - (11%)

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |:|:||||.|||:|.|......|.::||.......:..|.| |:||||.:.||..:........:
  Rat     4 ESVKVVVRCRPMNKRERELNCQSVVTVDCARGQCFIQNPGA-ADEPPKQFTFDGAYYIEHFTEQI 67

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:.|.|:|:.|.|||||||.||||||:||::||.|.||.|..:||||.||.|:|..: :..||.
  Rat    68 YNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPCQRGIIPRAFEHVFESV-QCAENT 131

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            |||||.||:|||||:||||||.|..:.||:||.|:.||:||.||.:.|||....|.:|..|.|||
  Rat   132 KFLVRASYLEIYNEDVRDLLGADTKQRLELKEHPEKGVYVKGLSMHTVHNVAQCERVMETGWKNR 196

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT 278
            |||.|.||::|||||:||:|.:|...:.|....|:|.|||.|||||||||||||.|:|:||||||
  Rat   197 AVGYTLMNKDSSRSHSIFTINIEIYAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEAT 261

  Fly   279 KINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTL 343
            |||||||.|||||||||||:..|||||:||||||||||||||:||:|.|.:||||:||.||:|||
  Rat   262 KINLSLSALGNVISALVDGRCKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTL 326

  Fly   344 RYASRAKNIQNRMHINEEPKDALLRHFQEEIARLR----KQLEEGDSLEEEPPSSEEEEDTADDE 404
            |||:|||||:|:..|||:|||||||.:||||.||:    :|:..|:
  Rat   327 RYANRAKNIKNKPRINEDPKDALLREYQEEIKRLKAILAQQMGPGN------------------- 372

  Fly   405 LEAPLEIELESSTIQAVEK--KPKKKREKTDAEK--------EELAKRKNEHQKEIEHAKTEQET 459
            |.|.|..:..|..:...||  .|...::.|:|||        |.||:.|.:::.|.|.....||.
  Rat   373 LSALLSTQTPSGPVHPEEKLPSPTTVQQDTEAEKQMIREEYEERLARLKADYEAEQESRVRLQED 437

  Fly   460 LRNKLVSLEGKILVGGENLLEKAQTQEL----------LLEQSIAELEQHE---KSEEALKQTLQ 511
            :.....|.:.|:....|||.::.:|..|          .:..:.|:...||   |:|...|..:.
  Rat   438 ITAMRNSYDVKLSTLQENLRKEKETGALCPGAAWEPTSCVPYTWAKGPLHEAVLKAEVLCKTEVM 502

  Fly   512 QKATERIDIEERYSTLQDASTGITKKIHRVMQML-----MGVKSELADQQQEHQREKEGIYENIR 571
            .:|  .:.....||......|.:...:..:..||     ...::.|..::...:..:..::|:..
  Rat   503 SRA--EVTSGPEYSPPLQYETAVKPTVLSMPDMLPRGEVTRSQAPLTSEEPNMEPSRSEVFESNE 565

  Fly   572 SLS-------------RELALCE------LVLNSYVPKEY 592
            |.:             .||:..|      |..:.|.|.||
  Rat   566 SSNLEDSSMSEAYPGPEELSNVEFSMPGVLAESRYFPDEY 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	198/332 (60%)
		Smc	<433..>578	CDD:440809	34/183 (19%)
Kif17	XP_038967234.1	Motor_domain	4..335	CDD:473979	198/332 (60%)