Protein Alignment Klp64D and sub

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 174/570 - (30%)
• Similarity: 259/570 - (45%)
• Gaps: 146/570 - (25%)

  Fly     4 EEANAGTTAQLDDEIE-NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATA---NEP 64
            |.|:..|:|.....:| ..:|.:|.||: |:...|..:|    ::.|..||..|.::|:   |..
  Fly    70 EGASCATSAADSSNVETGPQVFLRLRPV-KDASKAYIVS----EEANVLITSCKVDSTSNNVNRM 129

  Fly    65 PKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGI 129
            .|.:.|.::||....|.|:| ||.  :..|::|....||:.||.:|:|||||:.|:   ....||
  Fly   130 EKHFGFTSIFDSTVGQRDIY-DTC--VGPKIMEEECVTIMTYGTSGSGKTYTLLGD---DVRAGI 188

  Fly   130 IPNAFAHIF-----------------GHI------------------------------------ 141
            ||.|..:||                 |.|
  Fly   189 IPRALENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVI 253

  Fly   142 -------AKAKENQKFLVRVSYMEIYNEEVRDL---------LGKDVGKSLEVKERPDIG----V 186
                   .||..:...||.||::|||||.|.||         ||:...|:|::     :|    |
  Fly   254 DGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKI-----VGNKGHV 313

  Fly   187 FVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMG 251
            |:|.|:...|.::::...::|||.:.....:|.:|..|||||.:|::.:         :::.|.|
  Fly   314 FIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDI---------LKYNRSG 369

  Fly   252 -----KLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISA--LVDGKSTH--IPYRNS 307
                 ..:..|||||||.:.|..||.|||||..||.||.|||..:.|  .|..|...  ||||:|
  Fly   370 ITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDS 434

  Fly   308 KLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRH--- 369
            |||.|||.:|.|..|..|..|::|.|..|.|.::.|.:||.||||     |.:||  .:.:|
  Fly   435 KLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNI-----IFKEP--VIKQHRVS 492

  Fly   370 ---FQEEIARLRKQLEEGD---SLEEEPPSSE-EEEDTADDE------LEAPLEIELESSTIQAV 421
               |. |.::: ...|.||   .||:|....: |.|....|.      ||..|..|| ::|.|.:
  Fly   493 YCGFM-EFSKM-STCEGGDYTKELEDENVRLQLEIEQLKYDHVLQMQLLEEKLRREL-TATYQEI 554

  Fly   422 EKKPKKKREKTDAEKEELAKRKNE---------HQKEIEHAKTEQETLRN 462
            .:..||:.|....:|..:|:|::|         ::::||..|.|.|.|:|
  Fly   555 IQNNKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIEDLKDEIEELKN 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	132/418 (32%)
		Smc	<433..>578	CDD:440809	11/39 (28%)
sub	NP_611260.1	KISc	89..477	CDD:276812	129/412 (31%)
		GBP_C	<512..603	CDD:293879	25/91 (27%)
		coiled coil	576..586	CDD:293879	1/9 (11%)
		coiled coil	592..603	CDD:293879	5/10 (50%)