DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and Klp98A

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	219/774 - (28%)
Similarity:	344/774 - (44%)	Gaps:	204/774 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPN-ATANEPPKTYYFDNVFDGG---- 77
            :.:::|.||.||.:..|:...|...:.::  |:...::||. .:..:..:..:.|..||..
  Fly     1 MSSLKVAVRVRPFNSREIDMDAQLIMEME--NKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSF 63

  Fly    78 -------SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFA 135
                   :.|..:|.|....:||...||||..:.||||||:|||:||.|.|::|   |:||....
  Fly    64 DAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNP---GLIPRICE 125

  Fly   136 HIFGHIAKAKEN-QKFLVRVSYMEIYNEEVRDLL-GKDVGKSLEVKERPDIGVFVKDLSGYVVHN 198
            .:|..:...:|: ..:....||:|||||.|:||| .:..|..|.|:|...:|.:|::||.:.|.:
  Fly   126 ELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSD 190

  Fly   199 ADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSER 263
            .|:::..:..||..|...:|.||..||||||||:||..:: :...|:....:.|:.|||||||||
  Fly   191 FDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQA-VFMNDMPSETVSKIHLVDLAGSER 254

  Fly   264 QSKTQASGQRLKEATKINLSLSVLGNVISALVD------------------GKS---THIPYRNS 307
            .:.|.|:||||||...||.||..||:|||||.:                  |.|   .:||||:|
  Fly   255 ANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDS 319

  Fly   308 KLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQE 372
            .||.||:|||||||||:|.|.:||||.||.||:||||||:|||||.|:..:||:....|:|..:|
  Fly   320 ILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELRE 384

  Fly   373 EIARLRKQLEEGDSLEEEP--------PSSEEEEDTADDE-----------LEAPLEIELESSTI 418
            ||.:|:..| .||....:|        ...|.:|....:|           |:....:.|..|.:
  Fly   385 EINKLKSML-AGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGV 448

  Fly   419 QAV-------------------------EKKPKKKREKTD-AEKEELA----------------- 440
            ..|                         |.:.:...|..| |:..|||
  Fly   449 GVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGV 513

  Fly   441 -------------------KRKNEHQKEI---------------EHAKTEQETLRNKL-VSLEGK 470
                               :.|...|.:|               |.||..::..|::| :|....
  Fly   514 VTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSL 578

  Fly   471 ILVGGENLL-----------------EKAQTQELLLEQSIAEL-EQHEKSEEALKQTLQQKATER 517
            |....||||                 |:....:..:.:...|| :::.|..:.::..|:|...||
  Fly   579 ITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVER 643

  Fly   518 IDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELAD-------QQQE---------HQREKEGI 566
            :.:.::|.|          |:.::.:.|:.::.|..|       ::||         .::..|.:
  Fly   644 VQMHDQYKT----------KVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKV 698

  Fly   567 YENIRSLSRELALCELVLNS-------YVPKEYQSM------------INQYTHWNEDI 606
            ..:|  :.|:::..:..|:|       ||.||.|.:            |.:.|..|:::
  Fly   699 QIDI--VCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDEL 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	147/367 (40%)
		Kinesin	26..352	CDD:278646	145/360 (40%)
		RILP-like	<437..556	CDD:304877	31/195 (16%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	150/374 (40%)
		KISc	3..371	CDD:214526	150/373 (40%)
		Kinesin_assoc	370..478	CDD:292801	19/108 (18%)
		FHA	456..555	CDD:238017	10/98 (10%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437717
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24620at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950