Protein Alignment Klp64D and Kif19A

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Alignment Length: 726
• Identity: 207/726 - (28%)
• Similarity: 319/726 - (43%)
• Gaps: 173/726 - (23%)

  Fly    11 TAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNAT-----ANEPPKTYYF 70
            |||...| |.:.|.||.||              |::...|.|.|:...:.     ....|:.|.:
  Fly    27 TAQPAQE-ERLVVAVRVRP--------------SMEATERCIEVISGGSLLYDDGGKSRPRQYSY 76

  Fly    71 DNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNP---DSPQTK----- 127
            |:||....:|..:|..|..|:|..||.|.|..:.|||.||:|||:||.| |   ..|||.
  Fly    77 DHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLG-PVPRKKPQTSDRAPP 140

  Fly   128 --------------GIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEV 178
                          |::..|...||.||..| |.....|.:||:|||||.:||||  :.|..||:
  Fly   141 TASCDSTDVSSQDIGLMVRAIEDIFSHIESA-EAYSCRVSISYLEIYNELIRDLL--NPGGPLEL 202

  Fly   179 KE-RPDIGVFVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVE-RSELG 241
            :| .....:.|..||.....:..::.:::..|||.|.:..|..||.||||||:.||.|: |:.||
  Fly   203 REDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTPLG 267

  Fly   242 EGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRN 306
                  .:.|:|.|.|||||||..||:..|:||:|...||.||..|||||:.| .|.:.::.||:
  Fly   268 ------TKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGL-SGGARYVNYRD 325

  Fly   307 SKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNI----QNRMHINEEPKDALL 367
            |||||||:::|.|..||||.|.::|...:..||.:||.||.||.:|    ||.::| :|.||...
  Fly   326 SKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYI-DEFKDFPT 389

  Fly   368 RHFQ-------EEIARLRKQLEEGDSLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKP 425
            :|:|       :|::|||.::     |.|.|.|.                   .::...|.....
  Fly   390 KHYQSLVSELRDEVSRLRTKM-----LTERPRSG-------------------AAAAAAAAAASG 430

  Fly   426 KKKREKTDAEKEELAKRKNEHQKEIEHAK-------TEQETLRNKLVSLEGKILVGGENLLEKAQ 483
            ......:.|..|.:.::..:.:.|:.:.:       .:|..||.||:..|..:|    .|...|:
  Fly   431 SAGTAGSGAGSEAVQEQDEQRKTELRYLREQIVLTFKQQMKLRRKLLEAESHLL----GLELDAE 491

  Fly   484 TQELLL---------------------EQSIA------EL-----------EQHEKSEEALKQ-- 508
            .|.:::                     |.|:|      ||           |..|::|..|:|
  Fly   492 RQHMIISHWQGRIGKLYDAMGDDDIESEGSVALKNAWGELAAIEKETRRYKEIRERTEHELEQCR 556

  Fly   509 ----TLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSE-LADQQQEHQREKEGIYE 568
                .|:.:..|||..:|....|     .:..::|.:....:.:::| ||.|.:..:|:.:
  Fly   557 QKGVKLEDELPERISSDEERELL-----ALLCRVHELEADKVSLQAERLARQAELRRRDLQ---- 612

  Fly   569 NIRSLSRELALCELVLNSY----------VPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNNMRK 623
             :....|:..|||.:::|.          :|.|.:.:...|..      |.....|..:.:|..:
  Fly   613 -LLRAERQRRLCEDIISSQRRLIEEGNVDLPDELRELYGLYQQ------EIHAGVVTPSTSNYER 670

  Fly   624 HISAHKTSGKE 634
            .:....|:|.:
  Fly   671 KLPPIYTAGSD 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	137/361 (38%)
		Smc	<433..>578	CDD:440809	36/196 (18%)
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	136/360 (38%)
		SMC_prok_B	<393..672	CDD:274008	56/322 (17%)