Protein Alignment Klp64D and Klp61F

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Alignment Length: 762
• Identity: 228/762 - (29%)
• Similarity: 366/762 - (48%)
• Gaps: 131/762 - (17%)

  Fly     2 PQEEANAGTTAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPK 66
            ||:::|           :|::|.||.||::..|....:...:.|......:|   .:...::..|
  Fly    12 PQKKSN-----------QNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVT---RHTLDSKLTK 62

  Fly    67 TYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTK---- 127
            .:.||..|...|.|.|:|.....|::::||.|||.|:.||||||||||:||.|| ::.:.|
  Fly    63 KFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGN-ETAELKSSWE 126

  Fly   128 -----GIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEV--KERPDIG 185
                 ||||.|.:|:|..:...:  .::.:|:||:|:||||:.|||..|....:.:  .......
  Fly   127 DDSDIGIIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGS 189

  Fly   186 VFVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELG-EGDVQHVR 249
            |.::.|....||:.||:..::..|.:.|....|.||.:|||||.:|||.|...|.| ||: ..::
  Fly   190 VIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGE-DMLK 253

  Fly   250 MGKLQLVDLAGSERQSKT-QASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLL 313
            :|||.||||||||..||. ...|.|::|...||.||..||.||:|||| ::.|:|||.|||||||
  Fly   254 IGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLL 317

  Fly   314 QDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEE-PKDALLRHFQEEIARL 377
            |:||||.:||.:.|||||...:..||:|||.||.|||||||:..:|:: .|..:|:.:.|||.:|
  Fly   318 QESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKL 382

  Fly   378 RKQL-----EEGDSLEEE-------PPSSEEEE--------DTADDELEAPLEIELESSTIQAVE 422
            ::.|     :.|..|.||       ...|:..|        ....|||:...:|..|.| :..||
  Fly   383 KRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVS-MSLVE 446

  Fly   423 KKPKKKREKTD---------AEKEELAKRKNEHQKEIE----HAKTEQ--ETLRNKLVS------ 466
            |..:.|:.:.:         ..|:.|.|.|..::::.|    |.||||  .|...::::
  Fly   447 KTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLAT 511

  Fly   467 ---------------LEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATE 516
                           |:.||....:...::.|..   ||.....|..::..:.|||:.|.|:...
  Fly   512 DDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDN---LEMIGGSLNLYQDQQAALKEQLSQEMVN 573

  Fly   517 RIDIEERYS----------------TLQDASTGITKKIHRVM----QMLMGVKSELADQQQEHQ- 560
            ...:.:|.:                :|||.:....|.|..||    |......::|.:|.|:.|
  Fly   574 SSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQL 638

  Fly   561 -REKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTG------ 618
             ..|| |..|::.:.......:.:|:| :.:::.::|:......|:..:...|.:...|
  Fly   639 LMSKE-IQTNLQVIEENNQRHKAMLDS-MQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPD 701

  Fly   619 ----NNMRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPMRSKSA 661
                .|:::.::..:...::.|.|..|   :....:.:.| :|||::
  Fly   702 AEELQNLQEELANERALAQQEDALLES---MMMQMEQIKN-LRSKNS 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	143/345 (41%)
		Smc	<433..>578	CDD:440809	40/202 (20%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	149/366 (41%)
		SMC_prok_B	<408..728	CDD:274008	61/325 (19%)
		SMC_prok_B	<651..>921	CDD:274008	14/99 (14%)
		Microtub_bind	923..>1004	CDD:464048