DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and KIF3C

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_002245.4	Gene:	KIF3C / 3797	HGNCID:	6321	Length:	793	Species:	Homo sapiens

Alignment Length:	768	Identity:	306/768 - (39%)
Similarity:	441/768 - (57%)	Gaps:	115/768 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |.::||.|.||:.:.|.:||....:::|.....:|:..|.|...|.|||:.||.|:|..|.|.||
Human     9 EALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADL 73

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:|.||::|.||:|:|||:.|||||||||||||.|....|:.:|:|||||.|||.||::: :||
Human    74 YDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRS-QNQ 137

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            ::|||.||:|||.||:||||.|:.||.||:||.|:.||::||||.:|..|..::|::|.|||:.|
Human   138 QYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQTR 202

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKT----------- 267
            |||:|.||:.||||||||.||||.||.|.....|:|:|||.||||||||||:|.
Human   203 AVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATP 267

  Fly   268 -------------QASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGG 319
                         .|.|:|.|||:|||||||.|||||:||...:|||||||:|||||||||||||
Human   268 SSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGG 332

  Fly   320 NSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEG 384
            |:||:|.||:.||..:|.|::||||:|:|||||:|:..:||:|||.|||.||||||||:.|||:.
Human   333 NAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKR 397

  Fly   385 DSLEEEP--------------------PSSE----EEEDTADDELEAPLEIELESSTIQAVEKKP 425
            ..|.:.|                    |..|    ||||..::....|..| |||:..:.:|...
Human   398 GMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPI-LESALEKNMENYL 461

  Fly   426 KKKREKTDAEK-----------EELAKRKNEHQKEIEHAKTEQ---ETLRNKLVSLEGKILVGGE 476
            ::::|:.:.||           ||..|...|.:|.:|..:.||   |.|..|..::|.|:|:||.
Human   462 QEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESKLLIGGR 526

  Fly   477 NLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKIHRV 541
            |:::....|:.:||....|:.:.::.|..::|.:..:..|.:::...|::||......|||:.::
Human   527 NIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKTKKLKKL 591

  Fly   542 MQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDI 606
            ...|..||:|:.||..|:.|.::.:.|.....:|||.|..|::.:::|.|.::.|......:.:.
Human   592 YAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFLDCEE 656

  Fly   607 GEWQLKCVAYTG---NNMRKH----------ISAH----KTSGKEPDF---------LDLS--HV 643
            .:|:.:.:...|   :.|:|.          ||.:    ...|..|.:         ||:|  .|
Human   657 EQWKFQPLVPAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAV 721

  Fly   644 Y-LSYNTDGVSNP--------MRSKS--ARPRTSGV------------PRPTT 673
            : :.::.|...:|        ||..|  .||.||.|            |.|:|
Human   722 FEMEFSHDQEQDPRALHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPST 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	195/356 (55%)
		Kinesin	26..352	CDD:278646	192/349 (55%)
		RILP-like	<437..556	CDD:304877	35/121 (29%)
KIF3C	NP_002245.4	KISc_KIF3	9..365	CDD:276822	195/356 (55%)
		Kinesin	16..365	CDD:278646	192/349 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..288		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..424		3/28 (11%)
		GBP_C	<461..569	CDD:303769	27/107 (25%)
		coiled coil	538..549	CDD:293879	3/10 (30%)
		coiled coil	558..569	CDD:293879	2/10 (20%)
		Globular. /evidence=ECO:0000255	630..793		29/145 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	750..793		8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1240
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.670