DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and unc-104

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	231/732 - (31%)
Similarity:	336/732 - (45%)	Gaps:	189/732 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IENVRVVVRTRPMDKNELS---------AGALSAISVDKINRAITVMKPNATANEPPKTYYFDNV 73
            :.:|:|.||.||.:..|::         |||.:||:..|:       .||  .::..|.:.||..
  Fly     1 MSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKV-------PPN--TSDSVKRFNFDYS 56

  Fly    74 F------DGG-SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIP 131
            :      |.. |.|..:|.|....::....:|||..|.||||||.||:|||.|..:. |.:||||
  Fly    57 YWSHDHHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEE-QQEGIIP 120

  Fly   132 NAFAHIFGHIAKAK-ENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYV 195
            .....:|..|...: ::.|:.|.|||||||.|.|||||......:|.|:|.|.:|.:|:|||...
  Fly   121 MICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLA 185

  Fly   196 VHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSI--TVERSELGEGDVQHVRMGKLQLVDL 258
            |.:..|:.:::..|||.|.|.||.||:.||||||:|:|  |..|.:| ..::...::.|:.||||
  Fly   186 VTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDL-MTNLTTEKVSKISLVDL 249

  Fly   259 AGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD--------GKSTHIPYRNSKLTRLLQD 315
            |||||...|.|.|.||||...||.||:.||.|||||.:        .|:..||||:|.||.||::
  Fly   250 AGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRE 314

  Fly   316 SLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQ 380
            :|||||||.|.|.|||||.||.||:||||||.|||.|..:..:||:....|:|..:|||.:||..
  Fly   315 NLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDL 379

  Fly   381 LE-EGDSLEEE-----------PPSSEEEE----DTADDELEAPLEIELESSTIQAVEKKPKK-- 427
            |: ||..::||           |..|....    :.|.|:|:|..::..|.:  :..|:|.|:
  Fly   380 LKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELN--ETWEEKLKRTE 442

  Fly   428 ----KREKTDAE-----KEE------LAKRKNEH------------------------------- 446
                :||...||     ||:      .:.:|..|
  Fly   443 EIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEAN 507

  Fly   447 -----QKEIEHAKTEQETLRNK------------LVSLEGKILV--------------------- 473
                 |....|...|..|..||            ::.:.|:.||
  Fly   508 VPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRF 572

  Fly   474 -----------------GGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERID-I 520
                             ..||.:||..||:  ::.:.|:.|..||....||..::    :|:| :
  Fly   573 TNPEQARELRDKIETENEAENEVEKTDTQQ--VDWNFAQCELLEKQGIDLKAEMK----KRLDNL 631

  Fly   521 EERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREK-EGIYENIRSLSRELALCELVL 584
            ||:|.         .:|:.             ||||.|.||:. |...:.::....|.::...:.
  Fly   632 EEQYK---------REKLQ-------------ADQQFEEQRKTYEARIDALQKQVEEQSMTMSMY 674

  Fly   585 NSYVPKEYQSMINQYTH 601
            :||.|:::....:.||:
  Fly   675 SSYSPEDFHQEEDVYTN 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	157/359 (44%)
		Kinesin	26..352	CDD:278646	154/352 (44%)
		RILP-like	<437..556	CDD:304877	32/211 (15%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	158/366 (43%)
		KISc	3..358	CDD:214526	158/365 (43%)
		Kinesin_assoc	355..498	CDD:292801	32/144 (22%)
		FHA	475..574	CDD:238017	10/98 (10%)
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940