Protein Alignment Klp64D and unc-104

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 732
• Identity: 231/732 - (31%)
• Similarity: 336/732 - (45%)
• Gaps: 189/732 - (25%)

  Fly    18 IENVRVVVRTRPMDKNELS---------AGALSAISVDKINRAITVMKPNATANEPPKTYYFDNV 73
            :.:|:|.||.||.:..|::         |||.:||:..|:       .||  .::..|.:.||..
  Fly     1 MSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKV-------PPN--TSDSVKRFNFDYS 56

  Fly    74 F------DGG-SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIP 131
            :      |.. |.|..:|.|....::....:|||..|.||||||.||:|||.|..:. |.:||||
  Fly    57 YWSHDHHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEE-QQEGIIP 120

  Fly   132 NAFAHIFGHIAKAK-ENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYV 195
            .....:|..|...: ::.|:.|.|||||||.|.|||||......:|.|:|.|.:|.:|:|||...
  Fly   121 MICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLA 185

  Fly   196 VHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSI--TVERSELGEGDVQHVRMGKLQLVDL 258
            |.:..|:.:::..|||.|.|.||.||:.||||||:|:|  |..|.:| ..::...::.|:.||||
  Fly   186 VTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDL-MTNLTTEKVSKISLVDL 249

  Fly   259 AGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD--------GKSTHIPYRNSKLTRLLQD 315
            |||||...|.|.|.||||...||.||:.||.|||||.:        .|:..||||:|.||.||::
  Fly   250 AGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRE 314

  Fly   316 SLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQ 380
            :|||||||.|.|.|||||.||.||:||||||.|||.|..:..:||:....|:|..:|||.:||..
  Fly   315 NLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDL 379

  Fly   381 LE-EGDSLEEE-----------PPSSEEEE----DTADDELEAPLEIELESSTIQAVEKKPKK-- 427
            |: ||..::||           |..|....    :.|.|:|:|..::..|.:  :..|:|.|:
  Fly   380 LKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELN--ETWEEKLKRTE 442

  Fly   428 ----KREKTDAE-----KEE------LAKRKNEH------------------------------- 446
                :||...||     ||:      .:.:|..|
  Fly   443 EIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEAN 507

  Fly   447 -----QKEIEHAKTEQETLRNK------------LVSLEGKILV--------------------- 473
                 |....|...|..|..||            ::.:.|:.||
  Fly   508 VPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRF 572

  Fly   474 -----------------GGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERID-I 520
                             ..||.:||..||:  ::.:.|:.|..||....||..::    :|:| :
  Fly   573 TNPEQARELRDKIETENEAENEVEKTDTQQ--VDWNFAQCELLEKQGIDLKAEMK----KRLDNL 631

  Fly   521 EERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREK-EGIYENIRSLSRELALCELVL 584
            ||:|.         .:|:.             ||||.|.||:. |...:.::....|.::...:.
  Fly   632 EEQYK---------REKLQ-------------ADQQFEEQRKTYEARIDALQKQVEEQSMTMSMY 674

  Fly   585 NSYVPKEYQSMINQYTH 601
            :||.|:::....:.||:
  Fly   675 SSYSPEDFHQEEDVYTN 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	157/359 (44%)
		Smc	<433..>578	CDD:440809	42/243 (17%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	158/366 (43%)
		Kinesin_assoc	355..498	CDD:465047	32/144 (22%)
		FHA_KIF1	474..574	CDD:438757	10/99 (10%)
		YhaN	<575..>666	CDD:443752	26/118 (22%)
		KIF1B	878..924	CDD:463574
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939