DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Khc

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	694	Identity:	221/694 - (31%)
Similarity:	339/694 - (48%)	Gaps:	115/694 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANE----PPKTYYFDNVFDGGSN 79
            ::::||.|.||::.:|..||:           ...|..||.....    ..|.|.||.||...::
  Fly    11 DSIKVVCRFRPLNDSEEKAGS-----------KFVVKFPNNVEENCISIAGKVYLFDKVFKPNAS 64

  Fly    80 QMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKA 144
            |..:|.:.|:.||..||.||||||.|||||.:|||:||.|.......:||||.....||.||...
  Fly    65 QEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAM 129

  Fly   145 KENQKFLVRVSYMEIYNEEVRDLLGKDVGK-SLEVKERPDIGVFVKDLSGYVVHNADDLENIMRL 208
            :.|.:|.::|||.|||.:::||||  ||.| :|.|.|..:...:||..:...|.:.:|:..::..
  Fly   130 EVNLEFHIKVSYYEIYMDKIRDLL--DVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEE 192

  Fly   209 GNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQR 273
            |..||.:..|.||:.|||||::|.|.|::..|   :.|....|||.||||||||:.|||.|.|..
  Fly   193 GKSNRHIAVTNMNEHSSRSHSVFLINVKQENL---ENQKKLSGKLYLVDLAGSEKVSKTGAEGTV 254

  Fly   274 LKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYME 338
            |.||..||.|||.||||||||.||..||||||:|||||:||:|||||::|.:....|||..|..|
  Fly   255 LDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESE 319

  Fly   339 TISTLRYASRAKNIQNRMHINEE-PKDALLRHFQ---EEIARLRKQLEE----------GDSLEE 389
            |.|||.:..|||.::|.:.:||| ..:...|.::   |:.|||:.::|:          |::::
  Fly   320 TKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVK- 383

  Fly   390 EPPSSEEEEDTADDELEAPL-EIELESSTIQAVEKK-----------------PKKKREKTDAEK 436
                 .||:...:|.:||.. .:|:|::...|.|..                 .::.|..|:.|:
  Fly   384 -----AEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECER 443

  Fly   437 -------------------EELAKRKNEHQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKA 482
                               |:|.::..|.::.|.:|:.|.|||::::..::      .||...|.
  Fly   444 LYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQ------QENESAKE 502

  Fly   483 QTQELL---------LEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKI 538
            :.:|:|         .:|...|::...|..:||.:.||||.:...........|:|.|:...|
  Fly   503 EVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKK-- 565

  Fly   539 HRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLS--------RELALCELVLNSY------VP 589
             |:.:||..:..:|.:..|.....:..|...:.:|:        .:..:..|.::..      :.
  Fly   566 -RITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIA 629

  Fly   590 KEYQSMINQYTHWNEDIGEWQLKCVAYTGNNMRKHISAHKTSGK 633
            :...:|..|....|:.|.|::.....|     |..||.|:...|
  Fly   630 QRCSNMETQQADSNKKISEYEKDLGEY-----RLLISQHEARMK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	152/337 (45%)
		Kinesin	26..352	CDD:278646	150/330 (45%)
		RILP-like	<437..556	CDD:304877	31/127 (24%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	152/337 (45%)
		KISc	12..340	CDD:214526	153/343 (45%)
		Apolipoprotein	595..744	CDD:279749	13/79 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24620at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950