Protein Alignment Klp64D and cos

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_477092.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Alignment Length: 704
• Identity: 167/704 - (23%)
• Similarity: 286/704 - (40%)
• Gaps: 207/704 - (29%)

  Fly     5 EANAGTTAQLD--DEIENVRVVVRTRPMDKNELSAGALSAIS-------VDKINRAITVMKPNAT 60
            :||...:.|.|  |....|:.:         .:||.||...|       :|.|...:..:.|:..
  Fly    81 DANGNDSGQKDYPDSAYCVQAI---------PISASALGLPSALPGGDPMDSIAAGLIQVGPHTV 136

  Fly    61 ANEPPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSP- 124
                |.|:    .....|:|..:|..|..|::...|||::.:::.|||.|.||:||:.||...|
  Fly   137 ----PVTH----ALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPT 193

  Fly   125 ---QTKGIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGV 186
               .|:|::......||.||:...| :.:.:.|.::||...:|.||||  :|.
  Fly   194 LTDSTEGVVQLCVRDIFSHISLHPE-RTYAINVGFVEICGGDVCDLLG--MGN------------ 243

  Fly   187 FVKDLSGYVVH--NADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELG-EGDVQHV 248
                     :|  |.|.:.:.:::|...|         :|..:|.:|::|:|:..:. ||.:||
  Fly   244 ---------IHCTNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQH- 289

  Fly   249 RMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD-----GKSTHIPYRNSK 308
            |:......||.|:|| ...|..|:.|      :..|.:|..|||.|.|     |.:.:|||..:.
  Fly   290 RLSTASFSDLCGTER-CGDQPPGRPL------DAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTT 347

  Fly   309 LTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKD--------- 364
            ||.||:||.||.::|::...:||.:.:..||:..|::|.:.:.::|.:.:|....|
  Fly   348 LTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAE 412

  Fly   365 --------------------------------------------------------------ALL 367
                                                                          .|.
  Fly   413 PVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLK 477

  Fly   368 RHFQE-----EIARLRKQL------EE-----GDSLEEEPPSSEEEEDTADDELEAPLEIELESS 416
            :..:|     |..|.:|||      ||     .::...|.|:|:.|.|| |:|...|   :|:..
  Fly   478 QECEECLSSTEAMRQQKQLVPILEAEEPEDVNSEAANSESPNSDNENDT-DNESHRP---DLDDK 538

  Fly   417 TIQAVEKKPKKKREKTDA---EK--EELAKR----KNEHQKEIEHAKTEQETLRNKLVSL--EGK 470
                :|...::.|:||||   ||  |.|:|.    .....:||| |:..:|...::.||:  ..:
  Fly   539 ----IESLMEEFRDKTDALILEKHAEYLSKHPKAVMQSQDREIE-AQPPEENGDDRKVSIGSRRR 598

  Fly   471 ILVGGENLLEKAQTQELLLEQSIAELEQHEKSE-EALKQTLQQKATERIDIEERYSTLQDASTGI 534
            .:..|.:|    .|.||.:...:|..:.....: |::...|:..:.|.|    |.:.|  |:...
  Fly   599 SVQPGASL----STAELAMLNRVASQQPPPPIDPESVVDPLESSSGEGI----RQAAL--AAAAA 653

  Fly   535 TKKIHRVMQMLMGVKSELADQQQEHQREKEGIY--ENIRSLSRELALCELVLNS 586
            |..|.::.:.|..:.:|:..:|::.:..:|.|.  :||        :.|||.||
  Fly   654 TAPIEQLQKKLRKLVAEIEGKQRQLREIEETIQVKQNI--------IAELVKNS 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	95/351 (27%)
		Smc	<433..>578	CDD:440809	36/158 (23%)
cos	NP_477092.1	Kinesin	140..389	CDD:459720	84/293 (29%)
		SMC_N	660..>999	CDD:481474	12/48 (25%)