Protein Alignment Klp64D and klp-20

DIOPT Version :9

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_497178.1
• Gene: klp-20 / 3565057
• WormBaseID: WBGene00002230
• Length: 646
• Species: Caenorhabditis elegans
• Alignment Length: 660
• Identity: 333/660 - (50%)
• Similarity: 443/660 - (67%)
• Gaps: 45/660 - (6%)

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |.|:||||.||:...|...|...|::.:...:|:.:  .:.:..:||:|:|||.||...::||.:
 Worm     5 EKVKVVVRCRPISTTEKLQGHKIAVTCNDEEKAVNI--KSLSQEDPPRTFYFDAVFSPNTDQMTV 67

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |...|||||:.||:||||||.||||||||||:||:|:.:..:.:|||||:|||||.||||.:.:.
 Worm    68 YNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGDLEPVEMRGIIPNSFAHIFDHIAKCQHDT 132

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            .|||||||:||||||:||||.||...:||:|||||:||:|::||...|.||..::.:|..|:|||
 Worm   133 TFLVRVSYLEIYNEEIRDLLSKDHNGNLEIKERPDVGVYVRNLSNPTVENASKMQALMEFGSKNR 197

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT 278
            .||||.||.|||||||:|::|:|....|     .|..|||||||||||||||||.|.|:|||||.
 Worm   198 KVGATAMNLESSRSHAMFTVTIESCRNG-----LVTQGKLQLVDLAGSERQSKTGAQGERLKEAA 257

  Fly   279 KINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTL 343
            |||||||.||||||:||||||||||||||||||||||||||||||||.|.:.||..||.||:|||
 Worm   258 KINLSLSTLGNVISSLVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMIANVGPATYNYDETLSTL 322

  Fly   344 RYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEEDTADDELEAP 408
            |||:|||||||...|||:||||.||.||.||..|||.|:     ||.|...|.:|:..:.:::
 Worm   323 RYANRAKNIQNVAKINEDPKDAQLRKFQLEIEALRKILD-----EENPGDDENQEEAWEAKMQ-- 380

  Fly   409 LEIELESSTIQAVEKKPKKKREK-----TDAEKEELAKRKNEHQKEIEHAKTEQETLRNKLVSLE 468
             |.|:|      :|||.|...|:     .|.|...|.|...|::.|::.|::|.|.||:||..:|
 Worm   381 -EREVE------MEKKRKILEERVNSAVNDEETHRLVKEMMENEAELKKARSEHEKLRSKLEKIE 438

  Fly   469 GKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTG 533
            .|::|||||||||.:.|..|||.:..||||.:..|..|:..|:::...:::||||||:||:.:..
 Worm   439 KKLIVGGENLLEKVEEQAKLLEVNNKELEQSKFQEAHLRTQLEERTAVKVEIEERYSSLQEEAFV 503

  Fly   534 ITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQ 598
            .:|||.:|...|...::||.|.:::|||:.|.:.::||.|.:||.|...:::.|:|.|:..:|.:
 Worm   504 KSKKIKKVSNELKDARAELKDLEEDHQRQVEAMLDDIRQLRKELLLNIAIIDEYIPVEHVELIEK 568

  Fly   599 YTHWNEDIGEWQLKCVAYTGNNMRKHISAHKTSGKEPDFLDLSH------VYLSYNTD-GVSNPM 656
            |..|:|:.|:||||.:||||||||        :...|...:.|:      :|.||..| |.|
 Worm   569 YVSWSEEHGDWQLKAIAYTGNNMR--------ASAPPAKKEFSNNNQTVPMYYSYRADLGAS--- 622

  Fly   657 RSKSARPRTS 666
             :...|||||
 Worm   623 -TAEHRPRTS 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	205/332 (62%)
		Kinesin	26..352	CDD:278646	200/325 (62%)
		RILP-like	<437..556	CDD:304877	49/118 (42%)
klp-20	NP_497178.1	Motor_domain	5..331	CDD:328930	205/332 (62%)
		SMC_N	<325..>569	CDD:330553	103/257 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167147
Domainoid	1	1.000	392	1.000	Domainoid score	I396
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38266
Inparanoid	1	1.050	599	1.000	Inparanoid score	I516
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0001102
OrthoInspector	1	1.000	-	-		oto20336
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	1	1.000	-	-		X4842
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790