DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Klp31E

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster

Alignment Length:	737	Identity:	233/737 - (31%)
Similarity:	355/737 - (48%)	Gaps:	136/737 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDLY 84
            :|||.||.||.:..||       |.:.:|...:|:.:|...... .|.:.||.|||..|||.|:|
  Fly    13 SVRVAVRIRPQNSREL-------IDMCRICTTVTLGEPQIFLGS-DKAFTFDYVFDTNSNQCDIY 69

  Fly    85 VDTARPIVDKVLEGYNGTILAYGQTGTGKTYTM-------SGNPDSPQTKGIIPNAFAHIFGHIA 142
            .|....:||..|.|||.|:|||||||:||||||       |.:.||.|. ||||.|..|||..|.
  Fly    70 SDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQL-GIIPRAVRHIFSGIE 133

  Fly   143 K-----------AKENQKFLVRVSYMEIYNEEVRDLLGK-DVGKSLEVKERPDIGVFVKDLSGYV 195
            :           |..:.:|.:.|.|:|:|||::.|||.. :...:.::.|.....:.:...|...
  Fly   134 QLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKP 198

  Fly   196 VHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSEL-------GEGDVQHVRMGKL 253
            ::...|....::.|...|...:||||.:||||||:|:|.|.|..|       .:.|::.: ..|.
  Fly   199 IYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETL-TSKF 262

  Fly   254 QLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD--GKSTHIPYRNSKLTRLLQDS 316
            ..||||||||..:|||:|:|.:|...||..|..|||.||||.|  .::.|:|||:||||||||||
  Fly   263 HFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDS 327

  Fly   317 LGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQL 381
            |||||:|:|.|.:||:|.::|||::||:||:||:||:|::.||::.....:...:.|||.|:.:|
  Fly   328 LGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLEL 392

  Fly   382 EE--GDSLEEEPPSSEEEEDTADD------ELEAPLEIELES--STIQAVEKKPKKKREKTDAEK 436
            .|  ...|..:...:....||.::      |::. |:..|:|  |||..:.::....:...|..|
  Fly   393 LEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKR-LQQRLKSLQSTIATLTQRNADLKTNLDLNK 456

  Fly   437 --------EELAKRKNEHQKEIEHAKT---EQETLRNKLVSLEGKILVGGEN--------LLEKA 482
                    .|:||...::..|||..:|   |.|..|.:   :|.|......|        ::.||
  Fly   457 WTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQ---MEIKATTSPRNAKPVYDSDIITKA 518

  Fly   483 -----QTQELLLEQSIAELE-QHEKSEEALKQTLQQKATERI--------DIEERYSTLQDASTG 533
                 :.:|||:.:|:..:: |:..|||....:...:|.|.:        |||.|
  Fly   519 KKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVKDLEAIDNDIEMR---------- 573

  Fly   534 ITKKIHRVMQMLMGVKSELADQQQEHQREKEGI----YENIRSLSRELALCELVLNSYVPK---- 590
             ||.|.:     :.:.:...:|.:.|..||..:    .||.:. .|:..|..:..:...|.
  Fly   574 -TKLIEQ-----LELTNSRYEQMRTHYEEKLSVLYCKIENTQK-ERDDVLANMTTSVSTPSKDSL 631

  Fly   591 -----EYQSMINQYTHWNEDIGEWQLKCVAYTGNNMRKHI------SAHK----TSGKEPDFLDL 640
                 :|:|.|   :|...:|.:.|        |..|:||      .:|:    |...|.:.|..
  Fly   632 KKVKTDYESKI---SHMQTEIRKLQ--------NAQREHIRSKQQLKSHEVRIGTLRNELNELKF 685

  Fly   641 SHVYLSYNTDGVSNPMRSKSAR 662
            :.|.|.......||..:.:.:|
  Fly   686 AKVKLMKKMSQQSNRHKQEESR 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	150/359 (42%)
		Kinesin	26..352	CDD:278646	146/353 (41%)
		RILP-like	<437..556	CDD:304877	32/143 (22%)
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	151/360 (42%)
		KISc	13..370	CDD:214526	153/366 (42%)
		KASH_CCD	409..589	CDD:291334	43/199 (22%)
		RasGAP	<685..750	CDD:295371	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940